Effect of Certain Quinones on Adenosine Triphosphate Level in Human Bladder Cancer Cells

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Effect of Certain Quinones on Adenosine Triphosphate Level in Human Bladder Cancer Cells
	Zhu, H.; Wang, H.
刊名	INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
	2020-01
卷号	82 页码:1-6
关键词	Quinones ATP T24
ISSN号	0250-474X
英文摘要	The aim of this study was to reveal the relationship between four kinds of quinones and the ATP level in human bladder cancer T24 cells. Quinones could cause damage to T24 cells, and after 12 h exposure, IC50 values were in mu M, 74 for 2-chlorobenzoquinone, 82 for 2,5-dichloro-1,4-benzoquinone, 122 for 2,6-dichloro-1,4-benzoquinone and 45 for 2,3,6-trichloro-1,4-benzoquinone. Further, the mechanism of increased ATP level when exposed to the 4 quinones was studied. It could be due to increased reactive oxygen species level in T24 cells when exposed to these quinones, which suppressed the ATPase activity, leading to increased levels of ATP, which was dose-dependent. The higher the quinone concentration was, the higher the reactive oxygen species level and the ATPase activity was lower, leading to accumulation of more ATP in T24 cells. This study indicated that these 4 quinones could block energy metabolism in T24 cells which could lead to cell death.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/44662]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Zhu, H.,Wang, H.. Effect of Certain Quinones on Adenosine Triphosphate Level in Human Bladder Cancer Cells[J]. INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES,2020,82:1-6.
APA	Zhu, H.,&Wang, H..(2020).Effect of Certain Quinones on Adenosine Triphosphate Level in Human Bladder Cancer Cells.INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES,82,1-6.
MLA	Zhu, H.,et al."Effect of Certain Quinones on Adenosine Triphosphate Level in Human Bladder Cancer Cells".INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES 82(2020):1-6.