Bioaccumulation and transfer characteristics of dechlorane plus in human adipose tissue and blood stream and the underlying mechanisms

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Bioaccumulation and transfer characteristics of dechlorane plus in human adipose tissue and blood stream and the underlying mechanisms
	Yin, Jun-Fa; Li, Ji-Fang-Tong; Li, Xing-Hong; Yang, You-Lin; Qin, Zhan-Fen
刊名	SCIENCE OF THE TOTAL ENVIRONMENT
	2020-01-15
卷号	700 页码:1-13
关键词	Dechlorane plus Adipose tissue Serum Lipids
ISSN号	0048-9697
英文摘要	In this study, bioaccumulation and transfer characteristics of dechlorane plus (DP) were examined between human adipose tissue and matched maternal serum, and the possible transfer mechanism between tissues was further discussed. The median level of total DP was 971 pg g(-1) wet weight (ww) and 1.22 ng g(-1) lipid weight (lw) in adipose tissue, respectively, and was 34.7 pg g(-1 )ww and 3.98 ng g(-1) lw for serum, respectively. DP wet levels' positive association with fat contents of five types of human tissues indicated that DP distribution might be related to lipid-driven mechanism. However, the lipid-adjusted adipose-serum partitioning ratios were estimated to be 0.35 for syn-DP and 0.35 for anti-DP, accordingly, which implied that the DP distribution between serum and adipose tissues, was not only regulated by the tissue lipid contents. Both the internal mono-dechlorination of anti-DP, and stereo-selective behavior of DP isomers were not found in DP transfer from blood to adipose tissue. The marginal positive relationship was observed between serum levels and apolipoprotein A concentrations (p = 0.095 for total DP and 0.045 for syn-DP), and neither association was found between serum levels and thyroid hormone concentrations (THs). To our best knowledge, this is the first report about the accumulation relationship of DP between human adipose tissue and blood stream with the corresponding distribution-related mechanism. (C) 2019 Elsevier B.V. All rights reserved.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/44617]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Yin, Jun-Fa,Li, Ji-Fang-Tong,Li, Xing-Hong,et al. Bioaccumulation and transfer characteristics of dechlorane plus in human adipose tissue and blood stream and the underlying mechanisms[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2020,700:1-13.
APA	Yin, Jun-Fa,Li, Ji-Fang-Tong,Li, Xing-Hong,Yang, You-Lin,&Qin, Zhan-Fen.(2020).Bioaccumulation and transfer characteristics of dechlorane plus in human adipose tissue and blood stream and the underlying mechanisms.SCIENCE OF THE TOTAL ENVIRONMENT,700,1-13.
MLA	Yin, Jun-Fa,et al."Bioaccumulation and transfer characteristics of dechlorane plus in human adipose tissue and blood stream and the underlying mechanisms".SCIENCE OF THE TOTAL ENVIRONMENT 700(2020):1-13.