An unexpected antioxidant and redox activity for the classic copper-chelating drug penicillamine

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	An unexpected antioxidant and redox activity for the classic copper-chelating drug penicillamine
	Mao, Li; Huang, Chun-Hua; Shao, Jie; Qin, Li; Xu, Dan; Shao, Bo; Zhu, Ben-Zhan
刊名	FREE RADICAL BIOLOGY AND MEDICINE
	2020-02-01
卷号	147 页码:150-158
关键词	Penicillamine Antioxidant-like activity Tetrachlorohydroquinone Tetrachlorosemiquinone radical Redox reaction Autooxidation
ISSN号	0891-5849
英文摘要	Penicillamine has been widely-used clinically as a copper-chelating drug for the treatment of copper-overload in Wilson's disease. In this study, we found that penicillamine provided marked protection against cytotoxicity induced by tetrachlorohydroquinone (TCHQ), a major toxic metabolite of the well-known wood preservative pentachlorophenol, while other classic copper-chelating agents do not. We found, unexpectedly, that both TCHQ autooxidation and tetrachlorosemiquinone radical (TCSQ(center dot-)) formation were remarkably delayed by penicillamine. Further investigation showed that TCSQ(center dot-) was reduced back to TCHQ by penicillamine, with the concurrent formation of its corresponding disulfide. These data demonstrated that the protection by penicillamine against TCHQ-induced toxicity was not due to its classic Cu-chelating property, but rather to its reduction of the reactive TCSQ(center dot-) to the much less-reactive TCHQ. This is the first report of an unexpected antioxidant and redox activity for penicillamine, which might prove highly relevant to its biological activities.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/44600]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Mao, Li,Huang, Chun-Hua,Shao, Jie,et al. An unexpected antioxidant and redox activity for the classic copper-chelating drug penicillamine[J]. FREE RADICAL BIOLOGY AND MEDICINE,2020,147:150-158.
APA	Mao, Li.,Huang, Chun-Hua.,Shao, Jie.,Qin, Li.,Xu, Dan.,...&Zhu, Ben-Zhan.(2020).An unexpected antioxidant and redox activity for the classic copper-chelating drug penicillamine.FREE RADICAL BIOLOGY AND MEDICINE,147,150-158.
MLA	Mao, Li,et al."An unexpected antioxidant and redox activity for the classic copper-chelating drug penicillamine".FREE RADICAL BIOLOGY AND MEDICINE 147(2020):150-158.