Treating Acute Kidney Injury with Antioxidative Black Phosphorus Nanosheets

doi:10.1021/acs.nanolett.9b05218

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	Treating Acute Kidney Injury with Antioxidative Black Phosphorus Nanosheets
	Hou, JJ ; Wang, H ; Ge, ZL ; Zuo, TT ; Chen, Q ; Liu, XG ; Mou, S ; Fan, CH ; Xie, Y ; Wang, LH
刊名	NANO LETTERS
	2020
卷号	20 期号:2 页码:1447-1454
关键词	PREVENTION DISEASE
ISSN号	1530-6984
DOI	10.1021/acs.nanolett.9b05218
文献子类	期刊论文
英文摘要	Black phosphorus nanosheets (BPNSs) have been actively employed as nanomedicine agents for photothermal and photodynamic therapy by virtue of their unique optical properties. However, their chemical reactivity as a competent biomaterial has not been fully explored yet. Here, we report on the use of BPNSs as reactive oxygen species (ROS) scavengers to cure acute kidney injury (AKI) in mice. Importantly, in vivo analysis in mice revealed that BPNSs were preferably accumulated in kidney. We found that BPNSs alleviated oxidative-pressure-induced cellular apoptosis. In a ROS-triggered acute kidney injury (AKI) model, BPNSs effectively consumed ROS in kidney, demonstrating high efficacy for curing AKI. BPNSs also exhibited excellent biocompatibility and biodegradability, making them promising candidates for therapeutic treatment of AKI and other renal diseases.
语种	英语
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/33226]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
作者单位	1.Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Inst Mol Med, Shanghai 200240, Peoples R China 2.Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Nephrol, Shanghai 200127, Peoples R China 3.Univ Sci & Technol China, iChEM, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol, CAS Key Lab Interfacial Phys & Technol, Shanghai 201800, Peoples R China 5.Chinese Acad Sci, Shanghai Adv Res Inst, Shanghai Synchrotron Radiat Facil, Zhangjiang Lab, Shanghai 201210, Peoples R China 6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 7.Shanghai Jiao Tong Univ, Renji Hosp, Sch Chem & Chem Engn, Sch Med, Shanghai 200240, Peoples R China
推荐引用方式 GB/T 7714	Hou, JJ,Wang, H,Ge, ZL,et al. Treating Acute Kidney Injury with Antioxidative Black Phosphorus Nanosheets[J]. NANO LETTERS,2020,20(2):1447-1454.
APA	Hou, JJ.,Wang, H.,Ge, ZL.,Zuo, TT.,Chen, Q.,...&Wang, LH.(2020).Treating Acute Kidney Injury with Antioxidative Black Phosphorus Nanosheets.NANO LETTERS,20(2),1447-1454.
MLA	Hou, JJ,et al."Treating Acute Kidney Injury with Antioxidative Black Phosphorus Nanosheets".NANO LETTERS 20.2(2020):1447-1454.