Sensitive imagine of intact microvessels in vivo with synchrotron radiation

doi:10.1107/S2052252520008234

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	Sensitive imagine of intact microvessels in vivo with synchrotron radiation
	Wang, FX ; Zhou, PT ; Li, K ; Mamtilahun, M ; Tang, YH ; Du, GH ; Deng, B ; Xie, HL ; Yang, GY ; Xiao, TQ
刊名	IUCRJ
	2020
卷号	7 页码:793-802
关键词	COMPUTED-TOMOGRAPHY DRUG-DELIVERY ANGIOGRAPHY NANOPARTICLES CANCER BRAIN
ISSN号	2052-2525
DOI	10.1107/S2052252520008234
文献子类	期刊论文
英文摘要	Early stages of diseases, including stroke, hypertension, angiogenesis of tumours, spinal cord injuries, etc., are closely associated with the lesions of microvasculature. Rodent models of human vascular diseases are extensively used for the preclinical investigation of the disease evolution and therapy with synchrotron radiation. Therefore, non-invasive and in vivo X-ray imaging with high sensitivity and clarity is desperately needed to visualize the microvessels in live-animal models. Contrast agent is essential for the in vivo X-ray imaging of vessels and angiomatous tissue. Because of the non-rigid motion of adjacent tissues, the short circulation time and the intermittent flow of contrast agents in vessels, it is a great challenge for the traditional X-ray imaging methods to achieve well defined images of microvessels in vivo. In this article, move contrast X-ray imaging (MCXI) based on high-brightness synchrotron radiation is developed to overcome the intrinsic defects in conventional methods. Experiments with live rodents demonstrate the practicability of the MCXI method for sensitive and intact imaging of microvessels in vivo.
语种	英语
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/33130]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
作者单位	1.Shanghai Jiao Tong Univ, Sch Biomed Engn, Shanghai 200030, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Shanghai Adv Res Inst, Shanghai Synchrotron Radiat Facil, Zhangjiang Lab, Shanghai 201204, Peoples R China 4.Shanghai Jiao Tong Univ, Neurosci & Neuroengn Res Ctr, Med X Res Inst, Shanghai 200030, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
推荐引用方式 GB/T 7714	Wang, FX,Zhou, PT,Li, K,et al. Sensitive imagine of intact microvessels in vivo with synchrotron radiation[J]. IUCRJ,2020,7:793-802.
APA	Wang, FX.,Zhou, PT.,Li, K.,Mamtilahun, M.,Tang, YH.,...&Xiao, TQ.(2020).Sensitive imagine of intact microvessels in vivo with synchrotron radiation.IUCRJ,7,793-802.
MLA	Wang, FX,et al."Sensitive imagine of intact microvessels in vivo with synchrotron radiation".IUCRJ 7(2020):793-802.