Peptides Co-Assembling into Hydrangea-Like Microstructures

doi:10.1166/jnn.2020.17393

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	Peptides Co-Assembling into Hydrangea-Like Microstructures
	Guo, Z ; Shen, ZW ; Wang, YJ ; Tan, TY ; Zhang, Y
刊名	JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
	2020
卷号	20 期号:5 页码:3239-3245
关键词	PROTEIN SECONDARY STRUCTURE NEURODEGENERATIVE DISEASES AMYLOID HYPOTHESIS ALZHEIMERS-DISEASE DESIGN FIBERS SPECTROSCOPY AGGREGATION FIBRILS INSULIN
ISSN号	1533-4880
DOI	10.1166/jnn.2020.17393
文献子类	期刊论文
英文摘要	Supramolecular assembly in vitro is a simple and effective way to produce multi-level biostructures to mimic the self-assembly of biomolecules in organisms. The study on peptide assembly behaviors would benefit a lot to understand what goes on in life, as well as in the construction of plenty of functional biomaterials that have potential applications in various fields. Since cellular microenvironments are crowded and contain various biomolecules, studying protein and peptide co-assembly is of great interest. Here, we introduced the co-assembly of 5-FAM-ELVFFAE-NH2 (EE-7) and (CY5)-KLVFFAK-NH2 (KK-7), which are sequences derived from the core of the amyloid beta (A beta) peptide, a key protein in Alzheimer's diseases. Morphologic studies employing atomic force microscopy and scanning electron microscopy indicated that the co-assembled entities had a novel hydrangea-like microstructure, in contrast to micro-sheet structures formed from monocomponent EE-7 or KK-7, respectively. Fluorescence co-localization experiments confirmed that the hydrangea-like microstructures were indeed made of both EE-7 and KK-7. We suggest that the formation of the hydrangea-like microstructures is driven by both the electrostatic and hydrophobic interactions between EE-7 and KK-7. A molecular mechanism has been provided to explain the formation of the hydrangea-like microstructures.
语种	英语
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/33059]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
作者单位	1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Appl Phys, Key Lab Interfacial Phys & Technol, Shanghai 201800, Peoples R China 3.Chinese Acad Sci, Zhangjiang Lab, Shanghai Adv Res Inst, Shanghai 201210, Peoples R China
推荐引用方式 GB/T 7714	Guo, Z,Shen, ZW,Wang, YJ,et al. Peptides Co-Assembling into Hydrangea-Like Microstructures[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2020,20(5):3239-3245.
APA	Guo, Z,Shen, ZW,Wang, YJ,Tan, TY,&Zhang, Y.(2020).Peptides Co-Assembling into Hydrangea-Like Microstructures.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,20(5),3239-3245.
MLA	Guo, Z,et al."Peptides Co-Assembling into Hydrangea-Like Microstructures".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 20.5(2020):3239-3245.