Nucleic Acid Nanoprobes for Biosensor Development in Complex Matrices

doi:10.1007/s40242-020-9073-x

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	Nucleic Acid Nanoprobes for Biosensor Development in Complex Matrices
	Deng, MY ; Li, M ; Mao, XH ; Li, F ; Zuo, XL
刊名	CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
	2020
卷号	36 期号:2 页码:185-193
关键词	DNA NANOSTRUCTURES SMALL MOLECULES MESSENGER-RNA REAL-TIME TUMOR-CELLS I-MOTIF APTAMER STABILITY ORIGAMI SERUM
ISSN号	1005-9040
DOI	10.1007/s40242-020-9073-x
文献子类	期刊论文
英文摘要	Nucleic acid probes in living organisms play an essential role in therapeutics and diagnosis. Through the imaging and sensing of nucleic acid probes in complex biological matrices, a variety of diseases-related biological process, pathogenic process, or pharmacological responses to a therapeutic intervention have been discovered. However, a critical challenge of nucleic acid probes applied in complex matrices lies in enhancing the stability of nucleic acid probes, especially when it suffers from nuclease degradation and protein adsorption. In order to enhance the application of nucleic acid nanoprobes in complex matrices, great efforts have been devoted to improving the stability of probes operated in complex media, including construction of nucleic acid nanoprobes with nuclease resistance and protein adsorption resistance, sample pretreatment, anti-biofouling and signal correction. In this review, we aim to summarize recent advances in the stability of nucleic acid nanoprobes in complex matrices, including the methods of enhancing the stability of probes or signals, and the application of nucleic acid nanoprobes for disease diagnosis.
语种	英语
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/33041]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
作者单位	1.Chinese Acad Sci, Shanghai Inst Appl Phys, SSRF, CAS Key Lab Interfacial Phys & Technol,Div Phys B, Shanghai 201800, Peoples R China 2.Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Inst Mol Med, Shanghai 200127, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai 200127, Peoples R China
推荐引用方式 GB/T 7714	Deng, MY,Li, M,Mao, XH,et al. Nucleic Acid Nanoprobes for Biosensor Development in Complex Matrices[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2020,36(2):185-193.
APA	Deng, MY,Li, M,Mao, XH,Li, F,&Zuo, XL.(2020).Nucleic Acid Nanoprobes for Biosensor Development in Complex Matrices.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,36(2),185-193.
MLA	Deng, MY,et al."Nucleic Acid Nanoprobes for Biosensor Development in Complex Matrices".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 36.2(2020):185-193.