DNA Origami Radiometers for Measuring Ultraviolet Exposure

doi:10.1021/jacs.0c01254

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	DNA Origami Radiometers for Measuring Ultraviolet Exposure
	Fang, WN ; Xie, M ; Hou, XL ; Liu, XG ; Zuo, XL ; Chao, J ; Wang, LH ; Fan, CH ; Liu, HJ ; Wang, LH
刊名	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
	2020
卷号	142 期号:19 页码:8782-8789
关键词	UV NANOSTRUCTURES DAMAGE RADIATION STABILITY CANCER
ISSN号	0002-7863
DOI	10.1021/jacs.0c01254
文献子类	期刊论文
英文摘要	Ultraviolet (UV) light has long been known to damage nucleic acids. In this work, a DNA origami radiometer has been developed for measuring UV exposure by monitoring the morphological evolution of DNA origami nanostructures. Unlike linear DNA strands that tend to be degraded into small segments upon UV exposure, the structural complexity and interstrand connectivity of DNA origami remarkably alter the pathway of UV-induced DNA damage. A general pathway of expansion, distortion, and final disintegration is observed for DNA origami regardless of their shape and size; however the deformation kinetics is positively correlated with the number of nicks in the nanostructure. This structural continuity-dependent deformation can be translated into a DNA-based radiometer for measuring UV dose in the environment.
语种	英语
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/32809]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
作者单位	1.Chinese Acad Sci, Shanghai Adv Res Inst, Zhangjiang Lab, Shanghai Synchrotron Radiat Facil, Shanghai 201800, Peoples R China 2.Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Inst Mol Med,Shanghai Key Lab Nucle Acids Chem &, Shanghai 200240, Peoples R China 3.Shanghai Jiao Tong Univ, Frontiers Sci Ctr Transformat Mol, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China 4.Nanjing Univ Posts & Telecommun, Inst Adv Mat IAM, Key Lab Organ Elect & Informat Displays KLOEID, Nanjing 210046, Peoples R China 5.Nanjing Univ Posts & Telecommun, Sch Mat Sci & Engn, Nanjing 210046, Peoples R China 6.Tongji Univ, Sch Chem Sci & Engn, Key Lab Adv Civil Engn Mat,Minist Educ, Shanghai Res Inst Intelligent Autonomous Syst, Shanghai 200092, Peoples R China 7.Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol, Shanghai 201800, Peoples R China
推荐引用方式 GB/T 7714	Fang, WN,Xie, M,Hou, XL,et al. DNA Origami Radiometers for Measuring Ultraviolet Exposure[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2020,142(19):8782-8789.
APA	Fang, WN.,Xie, M.,Hou, XL.,Liu, XG.,Zuo, XL.,...&Wang, LH.(2020).DNA Origami Radiometers for Measuring Ultraviolet Exposure.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,142(19),8782-8789.
MLA	Fang, WN,et al."DNA Origami Radiometers for Measuring Ultraviolet Exposure".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 142.19(2020):8782-8789.