DNA Framework-Based Topological Cell Sorters

doi:10.1002/anie.202002020

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	DNA Framework-Based Topological Cell Sorters
	Yin, FF ; Li, M ; Mao, XH ; Li, F ; Xiang, XL ; Li, Q ; Wang, LH ; Zuo, XL ; Fan, CH ; Zhu, Y
刊名	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
	2020
卷号	59 期号:26 页码:10406-10410
关键词	NANOSTRUCTURES INTEGRIN FORCES TCR
ISSN号	1433-7851
DOI	10.1002/anie.202002020
文献子类	期刊论文
英文摘要	Molecular recognition in cell biological process is characterized with specific locks-and-keys interactions between ligands and receptors, which are ubiquitously distributed on cell membrane with topological clustering. Few topologically-engineered ligand systems enable the exploration of the binding strength between ligand-receptor topological organization. Herein, we generate topologically controlled ligands by developing a family of tetrahedral DNA frameworks (TDFs), so the multiple ligands are stoichiometrically and topologically arranged. This topological control of multiple ligands changes the nature of the molecular recognition by inducing the receptor clustering, so the binding strength is significantly improved (ca. 10-fold). The precise engineering of topological complexes formed by the TDFs are readily translated into effective binding control for cell patterning and binding strength control of cells for cell sorting. This work paves the way for the development of versatile design of topological ligands.
语种	英语
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/32803]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
作者单位	1.Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol, CAS Key Lab Interfacial Phys & Technol, Shanghai 201800, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Inst Mol Med, Shanghai 200127, Peoples R China 4.Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Frontiers Sci Ctr Transformat Mol, Shanghai 200127, Peoples R China 5.Chinese Acad Sci, Shanghai Adv Res Inst, Shanghai 201210, Peoples R China 6.East China Normal Univ, Sch Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200241, Peoples R China
推荐引用方式 GB/T 7714	Yin, FF,Li, M,Mao, XH,et al. DNA Framework-Based Topological Cell Sorters[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2020,59(26):10406-10410.
APA	Yin, FF.,Li, M.,Mao, XH.,Li, F.,Xiang, XL.,...&Zhu, Y.(2020).DNA Framework-Based Topological Cell Sorters.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,59(26),10406-10410.
MLA	Yin, FF,et al."DNA Framework-Based Topological Cell Sorters".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 59.26(2020):10406-10410.