Biomembrane induced in situ self-assembly of peptide with enhanced antimicrobial activity

doi:10.1039/c9bm01785b

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	Biomembrane induced in situ self-assembly of peptide with enhanced antimicrobial activity
	Shen, ZW ; Guo, Z ; Zhou, LM ; Wang, YJ ; Zhang, JJ ; Hu, J ; Zhang, Y
刊名	BIOMATERIALS SCIENCE
	2020
卷号	8 期号:7 页码:2031-2039
关键词	AMYLOID-LIKE FIBRILS MECHANICAL-PROPERTIES MEMBRANE NANOPARTICLES FIELD
ISSN号	2047-4830
DOI	10.1039/c9bm01785b
文献子类	期刊论文
英文摘要	Antimicrobial peptides (AMPs) as biocides are of great interest because they have the ability to combat antibiotic resistance. Normally, natural AMPs need to be rationally designed or modified for practical use as an antibiotic. Here, a novel AMP, termed FF8, which is a cationic octapeptide composed of arginine, lysine, and phenylalanine, was designed. The FF8 was found to self-assemble into nanofibers when induced by a negatively charged lipid membrane or pH is above 9.4. The fibers on the membrane broke the lipid membrane, forming pores and significantly reducing its fluidity. FF8 also exhibited enhanced antibacterial activity by significantly increasing the permeability of the inner and outer membranes of Escherichia coli (E. coli) and maintaining the pores of the inner membrane of cells, which caused continuous membrane leakage. Because of its high antibacterial activity, cytocompatibility, and cost-effectiveness, FF8 is a promising antibacterial material.
语种	英语
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/32731]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
作者单位	1.Univ Chinese Acad Sci, Beijing 100019, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Appl Phys, Key Lab Interfacial Phys & Technol, Shanghai 201800, Peoples R China 3.Chinese Acad Sci, Shanghai Adv Res Inst, Zhangjiang Lab, Shanghai 201210, Peoples R China
推荐引用方式 GB/T 7714	Shen, ZW,Guo, Z,Zhou, LM,et al. Biomembrane induced in situ self-assembly of peptide with enhanced antimicrobial activity[J]. BIOMATERIALS SCIENCE,2020,8(7):2031-2039.
APA	Shen, ZW.,Guo, Z.,Zhou, LM.,Wang, YJ.,Zhang, JJ.,...&Zhang, Y.(2020).Biomembrane induced in situ self-assembly of peptide with enhanced antimicrobial activity.BIOMATERIALS SCIENCE,8(7),2031-2039.
MLA	Shen, ZW,et al."Biomembrane induced in situ self-assembly of peptide with enhanced antimicrobial activity".BIOMATERIALS SCIENCE 8.7(2020):2031-2039.