Functional connectivity of amygdala subregions predicts vulnerability to depression following the COVID-19 pandemic | |
Zhang, Shudong2; Cui, Jian2; Zhang, Zhifang2; Wang, Yun2; Liu, Rui2,3; Chen, Xiongying2; Feng, Yuan2,3; Zhou, Jingjing2; Zhou, Yuan1,2,4; Wang, Gang2,3 | |
刊名 | Journal of Affective Disorders |
2021 | |
通讯作者邮箱 | zhouyuan@psych.ac.cn |
关键词 | Amygdala COVID-19 Vulnerability Depression Resting-state functional connectivity |
ISSN号 | 1573-2517 |
DOI | https://doi.org/10.1016/j.jad.2021.09.107 |
产权排序 | 3 |
文献子类 | 实证研究 |
英文摘要 | Background The amygdala is vital in processing psychological stress and predicting vulnerability or resilience to stress-related disorders. This study aimed to build the link between functional magnetic resonance imaging data obtained before the stress event and the subsequent stress-related depressive symptoms. Methods Neuroimaging data obtained before the coronavirus disease 2019 pandemic from 39 patients with major depressive disorder (MDD) and 61 health controls (HCs) were used in this study. The participants were divided retrospectively into four groups in accordance with the severity of depressive symptoms during the pandemic: remitted patients, non-remitted patients, depressed HCs (HCd) and non-depressed HCs (HCnd). Seed-based resting-state functional connectivity (rsFC) analyses of the amygdala and its subregions, including the centromedial (CM), the basolateral and the superficial (SF), were performed. Results Vulnerability to depression was suggested by decreased rsFC between the left CM amygdala and the bilateral lingual gyrus in the HCd group compared with the HCnd group, and decreased rsFC of the left CM or right SF amygdala with the precuneus and the postcentral gyrus in the HCd group compared with patients with MDD. No evidence supported the rsFC of the amygdala or its subregions as a biomarker for the resilience of patients with MDD to stress under antidepressant treatment. Limitations Smaller sample size and no longitudinal neuroimaging data. Conclusions Our findings suggested that the rsFC of amygdala subregions may represent a neurobiological marker of vulnerability to depression following stress. |
收录类别 | SSCI |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/40642] |
专题 | 心理研究所_中国科学院行为科学重点实验室 |
通讯作者 | Zhang, Shudong; Zhou, Yuan |
作者单位 | 1.Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China 2.The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China 3.Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing 100069, China 4.CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing 100101, China |
推荐引用方式 GB/T 7714 | Zhang, Shudong,Cui, Jian,Zhang, Zhifang,et al. Functional connectivity of amygdala subregions predicts vulnerability to depression following the COVID-19 pandemic[J]. Journal of Affective Disorders,2021. |
APA | Zhang, Shudong.,Cui, Jian.,Zhang, Zhifang.,Wang, Yun.,Liu, Rui.,...&Wang, Gang.(2021).Functional connectivity of amygdala subregions predicts vulnerability to depression following the COVID-19 pandemic.Journal of Affective Disorders. |
MLA | Zhang, Shudong,et al."Functional connectivity of amygdala subregions predicts vulnerability to depression following the COVID-19 pandemic".Journal of Affective Disorders (2021). |
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