Preservation Analysis on Spatiotemporal Specific Co-expression Networks Suggests the Immunopathogenesis of Alzheimer’s Disease | |
Liyuan Guo; Yushan Liu; Jing Wang | |
刊名 | Frontiers in Aging Neuroscience |
2021 | |
通讯作者邮箱 | guoly@psych.ac.cn ; wangjing@psych.ac.cn |
DOI | 10.3389/fnagi.2021.727928 |
产权排序 | 1 |
文献子类 | 实证研究 |
英文摘要 | The occurrence and development of Alzheimer’s disease (AD) is a continuous clinical and pathophysiological process, molecular biological, and brain functional change often appear before clinical symptoms, but the detailed underlying mechanism is still unclear. The expression profiling of postmortem brain tissue from AD patients and controls provides evidence about AD etiopathogenesis. In the current study, we used published AD expression profiling data to construct spatiotemporal specific coexpression networks in AD and analyzed the network preservation features of each brain region in different disease stages to identify the most dramatically changed coexpression modules and obtained AD-related biological pathways, brain regions and circuits, cell types and key genes based on these modules. As result, we constructed 57 spatiotemporal specific networks (19 brain regions by three disease stages) in AD and observed universal expression changes in all 19 brain regions. The eight most dramatically changed coexpression modules were identified in seven brain regions. Genes in these modules are mostly involved in immune response-related pathways and non-neuron cells, and this supports the immune pathology of AD and suggests the role of blood brain barrier (BBB) injuries. Differentially expressed genes (DEGs) meta-analysis and protein–protein interaction (PPI) network analysis suggested potential key genes involved in AD development that might be therapeutic targets. In conclusion, our systematical network analysis on published AD expression profiling data suggests the immunopathogenesis of AD and identifies key brain regions and genes. |
URL标识 | 查看原文 |
收录类别 | SCI |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/40699] |
专题 | 心理研究所_健康与遗传心理学研究室 |
通讯作者 | Liyuan Guo; Jing Wang |
作者单位 | 1.CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China 2.College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China 3.Department of Psychology, University of Chinese Academy of Sciences, Beijing, China |
推荐引用方式 GB/T 7714 | Liyuan Guo,Yushan Liu,Jing Wang. Preservation Analysis on Spatiotemporal Specific Co-expression Networks Suggests the Immunopathogenesis of Alzheimer’s Disease[J]. Frontiers in Aging Neuroscience,2021. |
APA | Liyuan Guo,Yushan Liu,&Jing Wang.(2021).Preservation Analysis on Spatiotemporal Specific Co-expression Networks Suggests the Immunopathogenesis of Alzheimer’s Disease.Frontiers in Aging Neuroscience. |
MLA | Liyuan Guo,et al."Preservation Analysis on Spatiotemporal Specific Co-expression Networks Suggests the Immunopathogenesis of Alzheimer’s Disease".Frontiers in Aging Neuroscience (2021). |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论