Gender differences in prevalence and clinical correlates of anxiety symptoms in first-episode and drug-naive patients with major depressive disorder | |
Yang, Wan-Qiu2,3; Qu, Miao4; Fang, Han-liu5; Phan, Andrew T.6; Wu, Hanjing Emily6; Lang, Xiao-E7; Zhang, Xiang-Yang1,8 | |
刊名 | COMPREHENSIVE PSYCHIATRY |
2021-11-01 | |
通讯作者邮箱 | zhangxy@psych.ac.cn (x.-y. zhang) |
卷号 | 111页码:7 |
关键词 | Gender differences Major depressive disorder (MDD) Comorbid anxiety with major depressive disorder First episode and drug naive (FEDN) patients |
ISSN号 | 0010-440X |
DOI | 10.1016/j.comppsych.2021.152275 |
产权排序 | 7 |
文献子类 | 实证研究 |
英文摘要 | Aim: Gender differences in major depressive disorder (MDD) are commonly reported; however, gender differences in first-episode and drug-naive (FEDN) patients with major depressive disorder remain unclear. This study aimed to examine potential gender differences in the prevalence and clinical correlates of comorbid anxiety in FEDN patients with MDD. Methods: A cross-sectional study was conducted with1718 FEDN patients with MDD. Patients' demographic and clinical data were collected and analyzed using standardized clinical evaluation forms. The Hamilton depression scale (HAMD), Hamilton anxiety scale (HAMA) and Positive and Negative Syndrome Scale (PANSS) were used to evaluate depression, anxiety and psychotic symptoms, respectively. Results: There were no gender-based differences in the comorbidity rates of MDD and anxiety disorders (male: 10.2% vs. female:12.7%, P = 0.123). The prevalence of MDD with severe anxiety symptoms in male patients was similar to that of female patients (80.8%vs. 80.1%, P = 0.749). Male MDD patients were younger, had earlier age of onset, and were less likely to be married. In both the male and female groups, HAMD scores, HAMA scores, suicide attempts, and psychotic symptoms in patients with severe anxiety symptoms were higher than those patients without severe anxiety symptoms (all p <= 0.001). Furthermore, binary logistic regression analysis showed that psychotic symptoms and suicide attempts significantly predicted severe anxiety symptoms in both male and female patients with MDD, while body mass index(BMI)significantly predicted severe anxiety symptoms in MDD females only. Conclusion: Our study showed that there were no gender differences in the prevalence of comorbid anxiety in FEDN patients with MDD. Suicide attempts and psychiatric symptoms were associated with severe anxiety symptoms in both men and women with MDD, whereas BMI was only correlated with severe anxiety symptoms in women. |
收录类别 | SCI |
资助项目 | CAS Pioneer Hundred Talents Program ; National Key R&D Program of China[2017YFE0103700] ; Double Top Program of Yunnan University |
WOS关键词 | MENTAL-HEALTH SURVEY ; ANXIOUS DEPRESSION ; COMORBID ANXIETY ; SEX-DIFFERENCES ; MOOD DISORDERS ; ASSOCIATION ; NETHERLANDS ; OBESITY ; OUTPATIENTS ; POPULATION |
WOS研究方向 | Psychiatry |
出版者 | W B SAUNDERS CO-ELSEVIER INC |
WOS记录号 | WOS:000703606000004 |
资助机构 | CAS Pioneer Hundred Talents Program ; National Key R&D Program of China ; Double Top Program of Yunnan University |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/40331] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Zhang, Xiang-Yang |
作者单位 | 1.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 2.Yunnan Univ, Mental Hlth Ctr, Kunming, Yunnan, Peoples R China 3.Yunnan Univ, Sch Ethnol & Sociol, Kunming, Yunnan, Peoples R China 4.Capital Med Univ, Xuan Wu Hosp, Neurol Dept, Beijing, Peoples R China 5.Qingdao Univ, Qingdao Mental Hlth Ctr, Qingdao, Peoples R China 6.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA 7.Shanxi Med Univ, Clin Med Coll 1, Hosp 1, Dept Psychiat, Taiyuan, Peoples R China 8.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Yang, Wan-Qiu,Qu, Miao,Fang, Han-liu,et al. Gender differences in prevalence and clinical correlates of anxiety symptoms in first-episode and drug-naive patients with major depressive disorder[J]. COMPREHENSIVE PSYCHIATRY,2021,111:7. |
APA | Yang, Wan-Qiu.,Qu, Miao.,Fang, Han-liu.,Phan, Andrew T..,Wu, Hanjing Emily.,...&Zhang, Xiang-Yang.(2021).Gender differences in prevalence and clinical correlates of anxiety symptoms in first-episode and drug-naive patients with major depressive disorder.COMPREHENSIVE PSYCHIATRY,111,7. |
MLA | Yang, Wan-Qiu,et al."Gender differences in prevalence and clinical correlates of anxiety symptoms in first-episode and drug-naive patients with major depressive disorder".COMPREHENSIVE PSYCHIATRY 111(2021):7. |
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