Anterior thalamic stimulation improves working memory precision

doi:10.1016/j.brs.2021.07.006

CORC > 心理研究所 > 中国科学院心理研究所 > 中国科学院心理健康重点实验室

	Anterior thalamic stimulation improves working memory precision
	Liu, Jiali 3,4; Yu, Tao 1,2; Wu, Jinfeng 3,4; Pan, Yali 4; Tan, Zheng 3,4; Liu, Ruobing 3,4; Wang, Xueyuan 1,2; Ren, Liankun 1,2; Wang, Liang 3,4
刊名	BRAIN STIMULATION
	2021-09-01
卷号	14 期号:5 页码:1073-1080
关键词	Anterior nucleus of thalamus Electrical stimulation Hippocampus Neural oscillations Working memory precision
ISSN号	1935-861X
DOI	10.1016/j.brs.2021.07.006
通讯作者	Wang, Liang(lwang@psych.ac.cn)
英文摘要	Background: The anterior nucleus of thalamus (ANT) has been suggested as an extended hippocampal system. The circuit of ANT and hippocampus has been widely demonstrated to be associated with memory function. Both lesions to each region and disrupting inter-regional information flow can induce working memory impairment. However, the role of this circuit in working memory precision remains unknown. Objective: To test the role of the hippocampal-anterior thalamic pathway in working memory precision, we delivered intracranially electrical stimulation to the ANT. We hypothesize that ANT stimulation can improve working memory precision. Methods: Presurgical epilepsy patients with depth electrodes in ANT and hippocampus were recruited to perform a color-recall working memory task. Participants were instructed to point out the color they were supposed to recall by clicking a point on the color wheel, while the intracranial EEG data were synchronously recorded. For randomly selected half trials, a bipolar electrical stimulation was delivered to the ANT electrodes. Results: We found that compared to non-stimulation trials, working memory precision judgements were significantly improved for stimulation trials. ANT electrical stimulation significantly increased spectral power of gamma (30-100 Hz) oscillations and decreased interictal epileptiform discharges (IED) in the hippocampus. Moreover, the increased gamma power during the pre-stimulus and retrieval period predicted the improvement of working memory precision judgements. Conclusion: ANT electrical stimulation can improve working memory precision judgements and modulate hippocampal gamma activity, providing direct evidence on the role of the human hippocampalanterior thalamic axis in working memory precision. (c) 2021 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
收录类别	SCI
资助项目	National Natural Science Foundation of China[31771255] ; National Natural Science Foundation of China[81771395] ; National Natural Science Foundation of China[32020103009] ; Strategic Priority Research Program of Chinese Academy of Science[XDB32010300] ; CAS Interdisciplinary Innovation Team[JCTD-2018-07]
WOS关键词	MEDIAL TEMPORAL-LOBE ; BRAIN-STIMULATION ; ELECTRICAL-STIMULATION ; GAMMA ; HIPPOCAMPUS ; ATTENTION ; SEQUENCE ; NETWORK ; PERFORMANCE ; PATHWAYS
WOS研究方向	Neurosciences & Neurology
语种	英语
出版者	ELSEVIER SCIENCE INC
WOS记录号	WOS:000697707200005
资助机构	National Natural Science Foundation of China ; Strategic Priority Research Program of Chinese Academy of Science ; CAS Interdisciplinary Innovation Team
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/40287]
专题	心理研究所_中国科学院心理健康重点实验室
通讯作者	Wang, Liang
作者单位	1.Capital Med Univ, Xuanwu Hosp, Beijing Inst Funct Neurosurg, Beijing, Peoples R China 2.Capital Med Univ, Beijing Key Lab Neuromodulat, Comprehens Epilepsy Ctr Beijing, Dept Neurol,Xuanwu Hosp, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 4.Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Liu, Jiali,Yu, Tao,Wu, Jinfeng,et al. Anterior thalamic stimulation improves working memory precision[J]. BRAIN STIMULATION,2021,14(5):1073-1080.
APA	Liu, Jiali.,Yu, Tao.,Wu, Jinfeng.,Pan, Yali.,Tan, Zheng.,...&Wang, Liang.(2021).Anterior thalamic stimulation improves working memory precision.BRAIN STIMULATION,14(5),1073-1080.
MLA	Liu, Jiali,et al."Anterior thalamic stimulation improves working memory precision".BRAIN STIMULATION 14.5(2021):1073-1080.