Interrelationships Between Oxidative Stress, Cytokines, and Psychotic Symptoms and Executive Functions in Patients With Chronic Schizophrenia

doi:10.1097/PSY.0000000000000931

CORC > 心理研究所 > 中国科学院心理研究所 > 中国科学院心理健康重点实验室

	Interrelationships Between Oxidative Stress, Cytokines, and Psychotic Symptoms and Executive Functions in Patients With Chronic Schizophrenia
	Wu, Zhi Wei 1,6; Yu, Hong Hua 5; Wang, Xuan 4; Guan, Heng Yong 4; Xiu, Mei Hong 3; Zhang, Xiang Yang 2
刊名	PSYCHOSOMATIC MEDICINE
	2021-06-01
卷号	83 期号:5 页码:485-491
关键词	schizophrenia cytokine oxidative stress interactive effect clinical symptoms executive function
ISSN号	0033-3174
DOI	10.1097/PSY.0000000000000931
通讯作者	Xiu, Mei Hong(xiumeihong97@163.com) ; Zhang, Xiang Yang(zhangxy9@gmail.com)
英文摘要	Objective Accumulating evidence has demonstrated that the pathophysiology of schizophrenia is involved in various abnormalities in oxidative stress markers and cytokines closely related to synaptic plasticity. However, the interactive effects among key cytokines, oxidative stress, and executive dysfunction and symptoms of schizophrenia have not been investigated yet. Methods A total of 189 patients with chronic schizophrenia and 60 controls were recruited in the current study. Tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-8, IL-6, and IL-2 levels; catalase, glutathione peroxidase, and superoxide dismutase (SOD) activities; and malondialdehyde (MDA) levels were determined in patients and controls. Executive function was evaluated by the Wisconsin card sorting tests, the verbal fluency tests, and the Stroop word-color test. Clinical symptoms were evaluated by the Positive and Negative Syndrome Scale. Results Relative to the controls, the patients had lower activities of SOD and glutathione peroxidase and levels of TNF-alpha, but higher levels of MDA, IL-8, IL-6, and IL-2 (all p values < .05). A significant negative relationship between SOD activity and IL-8 levels was found only in patients (beta = -0.44, p = .008). Furthermore, we found that an interactive effect of low TNF-alpha level and high MDA level was associated with negative symptoms (beta = -0.02, p = .01). Moreover, the interactive effects of IL-8 and MDA or IL-8 and SOD were correlated with executive function only in patients (beta = 0.23, p = .02; beta = 0.09, p = .03). Conclusions Our findings suggest that the interrelationships between oxidative stress markers and cytokines occur in schizophrenia patients, which may be the basis of their pathological mechanisms underlying clinical symptoms and cognitive dysfunction.
收录类别	SCI
资助项目	National Natural Science Foundation of China[81371477] ; National Natural Science Foundation of China[81000509] ; Shenzhen Found for Guangdong Provincial High-level Clinical Key Specialties[SZGSP013] ; Sanming Project of Medicine in Shenzhen[SZSM201812052]
WOS关键词	ANTIOXIDANT DEFENSE SYSTEMS ; 1ST EPISODE PSYCHOSIS ; NECROSIS-FACTOR-ALPHA ; PREFRONTAL CORTEX ; FREE-RADICALS ; CEREBROSPINAL-FLUID ; LIPID-PEROXIDATION ; NEGATIVE SYMPTOMS ; BIPOLAR DISORDER ; DOUBLE-BLIND
WOS研究方向	Psychiatry ; Psychology
语种	英语
出版者	LIPPINCOTT WILLIAMS & WILKINS
WOS记录号	WOS:000669432500012
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/39824]
专题	心理研究所_中国科学院心理健康重点实验室
通讯作者	Xiu, Mei Hong; Zhang, Xiang Yang
作者单位	1.Shenzhen Kangning Hosp, Dept Psychiat, Shenzhen, Guangdong, Peoples R China 2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 3.Peking Univ, HuiLongGuan Clin Med Sch, Beijing HuiLongGuan Hosp, Psychiat Res Ctr, Beijing, Peoples R China 4.Hebei Prov Rong Jun Hosp, Dept Psychiat, Baoding, Peoples R China 5.Yantai Automobile Engn Profess Coll, Yantai, Peoples R China 6.Shenzhen Mental Hlth Ctr, Shenzhen, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Wu, Zhi Wei,Yu, Hong Hua,Wang, Xuan,et al. Interrelationships Between Oxidative Stress, Cytokines, and Psychotic Symptoms and Executive Functions in Patients With Chronic Schizophrenia[J]. PSYCHOSOMATIC MEDICINE,2021,83(5):485-491.
APA	Wu, Zhi Wei,Yu, Hong Hua,Wang, Xuan,Guan, Heng Yong,Xiu, Mei Hong,&Zhang, Xiang Yang.(2021).Interrelationships Between Oxidative Stress, Cytokines, and Psychotic Symptoms and Executive Functions in Patients With Chronic Schizophrenia.PSYCHOSOMATIC MEDICINE,83(5),485-491.
MLA	Wu, Zhi Wei,et al."Interrelationships Between Oxidative Stress, Cytokines, and Psychotic Symptoms and Executive Functions in Patients With Chronic Schizophrenia".PSYCHOSOMATIC MEDICINE 83.5(2021):485-491.