Theta oscillations synchronize human medial prefrontal cortex and amygdala during fear learning | |
Chen, Si2,3; Tan, Zheng2,3; Xia, Wenran2,3; Gomes, Carlos Alexandre4; Zhang, Xilei2; Zhou, Wenjing1; Liang, Shuli5; Axmacher, Nikolai4,6; Wang, Liang2,3 | |
刊名 | SCIENCE ADVANCES |
2021 | |
通讯作者邮箱 | lwang@psych.ac.cn |
卷号 | 7期号:34页码:13 |
ISSN号 | 2375-2548 |
DOI | 10.1126/sciadv.abf4198 |
产权排序 | 1 |
英文摘要 | Numerous animal studies have demonstrated that fear acquisition and expression rely on the coordinated activity of medial prefrontal cortex (mPFC) and amygdala and that theta oscillations support interregional communication within the fear network. However, it remains unclear whether these results can be generalized to fear learning in humans. We addressed this question using intracranial electroencephalography recordings in 13 patients with epilepsy during a fear conditioning paradigm. We observed increased power and inter-regional synchronization of amygdala and mPFC in theta (4 to 8 hertz) oscillations for conditioned stimulus (CS+) versus CS-. Analysis of information flow revealed that the dorsal mPFC (dmPFC) led amygdala activity in theta oscillations. Last, a computational model showed that trial-by-trial changes in amygdala theta oscillations predicted the model-based associability (i.e., learning rate). This study provides compelling evidence that theta oscillations within and between amygdala, ventral mPFC, and dmPFC constitute a general mechanism of fear learning across species. |
收录类别 | SCI ; SSCI ; EI |
资助项目 | Strategic Priority Research Program of Chinese Academy of Science[XDB32010300] ; National Key Research and Development Program of China[2016YFC1307200] ; Beijing Municipal Science and Technology Commission[Z171100000117014] ; National Natural Science Foundation of China[31771255] ; National Natural Science Foundation of China[32020103009] ; CAS Interdisciplinary Innovation Team[JCTD-2018-07] ; Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)[316803389-SFB 1280] ; Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)[122679504-SFB 874] |
WOS关键词 | ANTERIOR CINGULATE CORTEX ; DECISION-MAKING ; BASOLATERAL AMYGDALA ; EXTINCTION ; MEMORY ; MODEL ; EXPRESSION ; CIRCUITS ; RECALL ; EEG |
WOS研究方向 | Science & Technology - Other Topics |
语种 | 英语 |
出版者 | AMER ASSOC ADVANCEMENT SCIENCE |
WOS记录号 | WOS:000686461400004 |
资助机构 | Strategic Priority Research Program of Chinese Academy of Science ; National Key Research and Development Program of China ; Beijing Municipal Science and Technology Commission ; National Natural Science Foundation of China ; CAS Interdisciplinary Innovation Team ; Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/39926] |
专题 | 中国科学院心理研究所 |
作者单位 | 1.Tsinghua Univ, Yuquan Hosp, Epilepsy Ctr, Beijing, Peoples R China 2.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 4.Ruhr Univ Bochum, Inst Cognit Neurosci, Fac Psychol, Dept Neuropsychol, Bochum, Germany 5.Capital Med Univ, Funct Neurosurg Dept, Beijing Childrens Hosp, Beijing, Peoples R China 6.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Xinjiekouwai St 19, Beijing 100875, Peoples R China 7.Beijing Normal Univ, IDG McGovern Inst Brain Res, Xinjiekouwai St 19, Beijing 100875, Peoples R China |
推荐引用方式 GB/T 7714 | Chen, Si,Tan, Zheng,Xia, Wenran,et al. Theta oscillations synchronize human medial prefrontal cortex and amygdala during fear learning[J]. SCIENCE ADVANCES,2021,7(34):13. |
APA | Chen, Si.,Tan, Zheng.,Xia, Wenran.,Gomes, Carlos Alexandre.,Zhang, Xilei.,...&Wang, Liang.(2021).Theta oscillations synchronize human medial prefrontal cortex and amygdala during fear learning.SCIENCE ADVANCES,7(34),13. |
MLA | Chen, Si,et al."Theta oscillations synchronize human medial prefrontal cortex and amygdala during fear learning".SCIENCE ADVANCES 7.34(2021):13. |
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