Premnafulvol A: A Diterpenoid with a 6/5/7/3-Fused Tetracyclic Core and Its Biosynthetically Related Analogues from Premna fulva | |
Pu, De-Bing1,3; Du, Bao-Wen2; Chen, Wen3; Gao, Jun-Bo1; Hu, Kun1; Shi,Nan2; Li, Yi-Ming3; Zhang, Xing-Jie3; Zhang, Rui-Han3; Li, Xiao-Nian1 | |
刊名 | ORGANIC LETTERS |
2018 | |
卷号 | 20期号:19页码:6314-6317 |
ISSN号 | 1523-7060 |
DOI | 10.1021/acs.orglett.8b02845 |
产权排序 | 2 |
文献子类 | Article |
英文摘要 | Premnafulvol A (1), a unique diterpenoid featuring a 6/5/7/3-fused tetracyclic carbon skeleton, with three biosynthetically related analogues, premnafulvols B-D (2-4), were isolated from the aerial parts of Premna fulva. Structures of 1-4 were established by a combination of extensive spectroscopic analyses, quantum chemical calculations, and X-ray crystallography. Plausible biosynthetic pathways of 1-4 were proposed. Interestingly, 2 and 3 exhibited opposite effects on estrogen biosynthesis in human ovarian granulosa-like KGN cells by modulating the expression of aromatase. |
学科主题 | Organic Chemistry/polymer Science |
URL标识 | 查看原文 |
WOS关键词 | AROMATASE INHIBITORS ; THERAPY ; ROOTS |
WOS研究方向 | Chemistry |
语种 | 英语 |
出版者 | AMER CHEMICAL SOC |
WOS记录号 | WOS:000447118200072 |
内容类型 | 期刊论文 |
源URL | [http://210.75.237.14/handle/351003/30590] |
专题 | 国家天然药物工程技术研究中心_天然产物研究 |
作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Sichuan, Peoples R China; 3.Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ & Yunnan Prov, Kunming 650091, Yunnan, Peoples R China; |
推荐引用方式 GB/T 7714 | Pu, De-Bing,Du, Bao-Wen,Chen, Wen,et al. Premnafulvol A: A Diterpenoid with a 6/5/7/3-Fused Tetracyclic Core and Its Biosynthetically Related Analogues from Premna fulva[J]. ORGANIC LETTERS,2018,20(19):6314-6317. |
APA | Pu, De-Bing.,Du, Bao-Wen.,Chen, Wen.,Gao, Jun-Bo.,Hu, Kun.,...&Xiao, Wei-Lie.(2018).Premnafulvol A: A Diterpenoid with a 6/5/7/3-Fused Tetracyclic Core and Its Biosynthetically Related Analogues from Premna fulva.ORGANIC LETTERS,20(19),6314-6317. |
MLA | Pu, De-Bing,et al."Premnafulvol A: A Diterpenoid with a 6/5/7/3-Fused Tetracyclic Core and Its Biosynthetically Related Analogues from Premna fulva".ORGANIC LETTERS 20.19(2018):6314-6317. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论