Synthesis and inhibitory effect of 10-chlorocanthin-6-one on ovarian cancer HO8910PM cells

doi:10.1007/s10529-017-2438-7

CORC > 成都生物研究所 > 中国科学院成都生物研究所 > 国家天然药物工程技术研究中心 > 天然产物研究

	Synthesis and inhibitory effect of 10-chlorocanthin-6-one on ovarian cancer HO8910PM cells
	Li, Wenhua 2; Chen, Yuwen 1,2; Sheng, Yuwen 2; Xie, Zeyu 2; Tang, Yaxiong 2
刊名	BIOTECHNOLOGY LETTERS
	2018
卷号	40 期号:1 页码:23-30
关键词	Bim Cell apoptosis 10-Chlorocanthin-6-one Cytotoxicity Ovarian cancer cell line
ISSN号	0141-5492
DOI	10.1007/s10529-017-2438-7
产权排序	1
文献子类	Article
英文摘要	To synthesize and determine the antitumor activity of 10-chlorocanthin-6-one in ovarian cancer HO8910PM cells. Among the synthesized canthin-6-one analogs, 10-chlorocanthin-6-one was the most cytotoxic (IC50 = 4.9 mu M), as demonstrated by a dose-dependent cytotoxicity assay. Moreover, 10-chlorocanthin-6-one induced apoptosis through the activation of poly(ADP-ribose) polymerase and caspase-3 cleavage, upregulation of Bcl-2, and downregulation of Bim, x-linked inhibitor of apoptosis protein (XIAP), and survivin in HO8910PM cells. Furthermore, Bim RNA, upregulated in a concentration-dependent manner, and knockdown of Bim via short-hairpin RNAs attenuated the inhibitory effects of 10-chlorocanthin-6-one on HO8910PM cell growth. 10-Chlorocanthin-6-one inhibits cell proliferation and induces apoptosis in H08910PM cells. The underlying molecular mechanisms of 10-chlorocanthin-6-one include activation of the Bim-mediated mitochondrial apoptotic pathway via upregulation of Bim and downregulation of Bcl-2, XIAP, and survivin. These data suggest that Bim is a potential target of 10-chlorocanthin-6-one, further demonstrating its potential use in the prevention and treatment of ovarian cancer.
学科主题	Biotechnology ; Applied Microbiology
URL标识	查看原文
WOS关键词	STATISTICS ; SITE
WOS研究方向	Biotechnology & Applied Microbiology
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000424228200003
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/30388]
专题	国家天然药物工程技术研究中心_天然产物研究
作者单位	1.Sichuan Univ, Sch Life Sci & Engn, Chengdu, Sichuan, Peoples R China 2.Chinese Acad Sci, Chengdu Inst Biol, 9 Sect 4,Renmin Nan Rd, Chengdu 610041, Sichuan, Peoples R China;
推荐引用方式 GB/T 7714	Li, Wenhua,Chen, Yuwen,Sheng, Yuwen,et al. Synthesis and inhibitory effect of 10-chlorocanthin-6-one on ovarian cancer HO8910PM cells[J]. BIOTECHNOLOGY LETTERS,2018,40(1):23-30.
APA	Li, Wenhua,Chen, Yuwen,Sheng, Yuwen,Xie, Zeyu,&Tang, Yaxiong.(2018).Synthesis and inhibitory effect of 10-chlorocanthin-6-one on ovarian cancer HO8910PM cells.BIOTECHNOLOGY LETTERS,40(1),23-30.
MLA	Li, Wenhua,et al."Synthesis and inhibitory effect of 10-chlorocanthin-6-one on ovarian cancer HO8910PM cells".BIOTECHNOLOGY LETTERS 40.1(2018):23-30.