Fine-Tuning the Expression of Duplicate Genes by Translational Regulation in Arabidopsis and Maize

doi:10.3389/fpls.2019.00534

CORC > 成都生物研究所 > 中国科学院成都生物研究所 > 生物多样性与生态系统服务领域 > 中国科学院环境与应用微生物重点实验室

	Fine-Tuning the Expression of Duplicate Genes by Translational Regulation in Arabidopsis and Maize
	Wang, Sishuo 1,2,3; Chen, Youhua 2
刊名	FRONTIERS IN PLANT SCIENCE
	2019
卷号	10 页码:534
关键词	gene duplication genome evolution plant genomics translational regulation expression evolution
ISSN号	1664-462X
DOI	10.3389/fpls.2019.00534
产权排序	1
文献子类	Article
英文摘要	Plant genomes are extensively shaped by various types of gene duplication. However, in this active area of investigation, the vast majority of studies focus on the sequence and transcription of duplicate genes, leaving open the question of how translational regulation impacts the expression and evolution of duplicate genes. We explored this issue by analyzing the ribo- and mRNA-seq data sets across six tissue types and stress conditions in Arabidopsis thaliana and maize (Zea mays). We dissected the relative contributions of transcriptional and translational regulation to the divergence in the abundance of ribosome footprint (RF) for different types of duplicate genes. We found that the divergence in RF abundance was largely programmed at the transcription level and that translational regulation plays more of a modulatory role. Intriguingly, translational regulation is characterized by its strong directionality, with the divergence in translational efficiency (TE) globally counteracting the divergence in mRNA abundance, indicating partial buffering of the transcriptional divergence between paralogs by translational regulation. Divergence in TE was associated with several sequence features. The faster-evolving copy in a duplicate pair was more likely to show lower RF abundance, which possibly results from relaxed purifying selection compared with its paralog. A considerable proportion of duplicates displayed differential TE across tissue types and stress conditions, most of which were enriched in photosynthesis, energy production, and translation-related processes. Additionally, we constructed a database TDPDG-DB (http://www.plantdupribo.tk), providing an online platform for data exploration. Overall, our study illustrates the roles of translational regulation in fine-tuning duplicate gene expression in plants.
学科主题	Plant Sciences
URL标识	查看原文
WOS关键词	FUNCTIONAL DIVERGENCE ; PHYLOGENETIC ANALYSIS ; GENOME DUPLICATIONS ; DOSAGE-SENSITIVITY ; PROTEIN-SEQUENCE ; EVOLUTION ; REVEALS ; ROBUSTNESS ; ANCIENT ; POLYPLOIDY
WOS研究方向	Plant Sciences
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000467283300001
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/31021]
专题	食品安全与环境治理领域_中国科学院环境与应用微生物重点实验室
作者单位	1.Univ British Columbia, Fac Sci, Dept Bot, Vancouver, BC, Canada; 2.Chinese Acad Sci, Chengdu Inst Biol, Chengdu, Sichuan, Peoples R China; 3.Chinese Univ Hong Kong, Sch Life Sci, Sha Tin, Hong Kong, Peoples R China
推荐引用方式 GB/T 7714	Wang, Sishuo,Chen, Youhua. Fine-Tuning the Expression of Duplicate Genes by Translational Regulation in Arabidopsis and Maize[J]. FRONTIERS IN PLANT SCIENCE,2019,10:534.
APA	Wang, Sishuo,&Chen, Youhua.(2019).Fine-Tuning the Expression of Duplicate Genes by Translational Regulation in Arabidopsis and Maize.FRONTIERS IN PLANT SCIENCE,10,534.
MLA	Wang, Sishuo,et al."Fine-Tuning the Expression of Duplicate Genes by Translational Regulation in Arabidopsis and Maize".FRONTIERS IN PLANT SCIENCE 10(2019):534.