The microbiota-gut-brain interaction in regulating host metabolic adaptation to cold in male Brandt's voles (Lasiopodomys brandtii)

doi:10.1038/s41396-019-0492-y

CORC > 成都生物研究所 > 中国科学院成都生物研究所 > 生物多样性与生态系统服务领域 > 中国科学院环境与应用微生物重点实验室

	The microbiota-gut-brain interaction in regulating host metabolic adaptation to cold in male Brandt's voles (Lasiopodomys brandtii)
	Bo, Ting-Bei 2,3; Zhang, Xue-Ying 2,3; Wen, Jing 2,3; Deng, Ke 1,3; Qin, Xiao-Wei 3; Wang, De-Hua 2,3
刊名	ISME JOURNAL
	2019
卷号	13 期号:12 页码:3037-3053
ISSN号	1751-7362
DOI	10.1038/s41396-019-0492-y
产权排序	3
文献子类	Article
英文摘要	Gut microbiota play a critical role in orchestrating metabolic homeostasis of the host. However, the crosstalk between host and microbial symbionts in small mammals are rarely illustrated. We used male Brandt's voles (Lasiopodomys brandtii) to test the hypothesis that gut microbiota and host neurotransmitters, such as norepinephrine (NE), interact to regulate energetics and thermogenesis during cold acclimation. We found that increases in food intake and thermogenesis were associated with increased monoamine neurotransmitters, ghrelin, short-chain fatty acids, and altered cecal microbiota during cold acclimation. Further, our pair-fed study showed that cold temperature can alter the cecal microbiota independently of overfeeding. Using cecal microbiota transplant along with beta 3-adrenoceptor antagonism and PKA inhibition, we confirmed that transplant of cold-acclimated microbiota increased thermogenesis through activation of cAMP-PKA-pCREB signaling. In addition, NE manipulation induced a long-term alteration in gut microbiota structure. These data demonstrate that gut microbiota-NE crosstalk via cAMP signaling regulates energetics and thermogenesis during cold acclimation in male Brandt's voles.
学科主题	Environment/ecology
URL标识	查看原文
WOS关键词	CHAIN FATTY-ACIDS ; DES-ACYL GHRELIN ; DIET-INDUCED OBESITY ; SIGNALING PATHWAY ; ENERGY-METABOLISM ; ADIPOSE-TISSUE ; PYY SECRETION ; BODY-MASS ; THERMOGENESIS ; DIVERSITY
WOS研究方向	Environmental Sciences & Ecology ; Microbiology
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000497952500012
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/31014]
专题	食品安全与环境治理领域_中国科学院环境与应用微生物重点实验室
作者单位	1.Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Sichuan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 3.Chinese Acad Sci, Inst Zool, State Key Lab Integrated Management Pest Insects, Beijing 100101, Peoples R China;
推荐引用方式 GB/T 7714	Bo, Ting-Bei,Zhang, Xue-Ying,Wen, Jing,et al. The microbiota-gut-brain interaction in regulating host metabolic adaptation to cold in male Brandt's voles (Lasiopodomys brandtii)[J]. ISME JOURNAL,2019,13(12):3037-3053.
APA	Bo, Ting-Bei,Zhang, Xue-Ying,Wen, Jing,Deng, Ke,Qin, Xiao-Wei,&Wang, De-Hua.(2019).The microbiota-gut-brain interaction in regulating host metabolic adaptation to cold in male Brandt's voles (Lasiopodomys brandtii).ISME JOURNAL,13(12),3037-3053.
MLA	Bo, Ting-Bei,et al."The microbiota-gut-brain interaction in regulating host metabolic adaptation to cold in male Brandt's voles (Lasiopodomys brandtii)".ISME JOURNAL 13.12(2019):3037-3053.