A new triterpene diglycoside from the roots of Bupleurum chinense DC. and its inhibitory effect on adipogensis in 3T3-L1 cells

doi:10.1007/s00044-018-2279-5

CORC > 成都生物研究所 > 中国科学院成都生物研究所 > 生物多样性与生态系统服务领域 > 中国科学院山地生态恢复与生物资源利用重点实验室

	A new triterpene diglycoside from the roots of Bupleurum chinense DC. and its inhibitory effect on adipogensis in 3T3-L1 cells
	Feng, Yujing 2; Wu, Zhou-Wei 1; Luo, Yanyan 2; Chen, Liang 2; Cao, Yufeng 2; Wang, Lun 1; Yaseen, Aftab 1; Chen, Bin 1; Khan, Ashfaq Ahmad 4; Wang, Ming-Kui 1
刊名	MEDICINAL CHEMISTRY RESEARCH
	2019
卷号	28 期号:3 页码:239-245
关键词	Bupleurum chinense DC Triterpene diglycoside Tibesaikosaponin V
ISSN号	1054-2523
DOI	10.1007/s00044-018-2279-5
产权排序	2
文献子类	Article
英文摘要	A new triterpene diglycoside, tibesaikosaponin V (TKV), was isolated from the methanol extract of the roots of Bupleurum chinense DC. by normal and reversed phase column chromatography. The chemical structure of this new compound was elucidated based on extensive spectroscopic analysis, including 1D and 2D NMR, HR-ESI-MS, and chemical degradation method. Our results indicated that TKV inhibited lipid accumulation and triacylglycerol content occurred without cytotoxicity to 3T3-L1 adipocytes. Furthermore, TKV significantly suppressed the mRNA expression of nuclear transcription factors such as, peroxisome proliferator-activated receptor (PPAR) and CCAAT/enhancer binding protein (C/EBP). These results suggest that TKV shows the ability to inhibit 3T3-L1 preadipocyte differentiation of and may have therapeutic potential for obesity and its associated metabolic disorders.
学科主题	Chemistry & Analysis
URL标识	查看原文
WOS关键词	SAIKOSAPONIN-D ; GLUCOSE-UPTAKE ; GLYCOSIDES ; ADIPOKINES ; APOPTOSIS ; PATHWAY
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	SPRINGER BIRKHAUSER
WOS记录号	WOS:000459449600002
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/31124]
专题	生物多样性与生态系统服务领域_中国科学院山地生态恢复与生物资源利用重点实验室
作者单位	1.Chinese Acad Sci, Key Lab Mt Ecol Restorat & Bioresource Utilizat,Ecol Restorat Biodivers Conservat Key Lab Sichuan, Chengdu Inst Biol, Chengdu 610041, Sichuan, Peoples R China; 2.Huaiyin Normal Univ, Jiangsu Collaborat Innovat Ctr Reg Modern Agr & E, Jiangsu Key Lab Ecoagr Biotechnol Hongze Lake, Huaian 223300, Peoples R China; 3.Nanjing Med Univ, Affiliated Huaian Peoples Hosp 1, Dept Gerontol, Huanghe West Rd, Huaian 223300, Peoples R China 4.Women Univ Azad Jammu & Kashmir, Dept Chem, Bagh 12500, Pakistan;
推荐引用方式 GB/T 7714	Feng, Yujing,Wu, Zhou-Wei,Luo, Yanyan,et al. A new triterpene diglycoside from the roots of Bupleurum chinense DC. and its inhibitory effect on adipogensis in 3T3-L1 cells[J]. MEDICINAL CHEMISTRY RESEARCH,2019,28(3):239-245.
APA	Feng, Yujing.,Wu, Zhou-Wei.,Luo, Yanyan.,Chen, Liang.,Cao, Yufeng.,...&Hu, Weicheng.(2019).A new triterpene diglycoside from the roots of Bupleurum chinense DC. and its inhibitory effect on adipogensis in 3T3-L1 cells.MEDICINAL CHEMISTRY RESEARCH,28(3),239-245.
MLA	Feng, Yujing,et al."A new triterpene diglycoside from the roots of Bupleurum chinense DC. and its inhibitory effect on adipogensis in 3T3-L1 cells".MEDICINAL CHEMISTRY RESEARCH 28.3(2019):239-245.