Flavonoids from the seeds of Oroxylum indicum and their anti-inflammatory and cytotoxic activities

doi:10.1016/j.phytol.2019.05.003

CORC > 成都生物研究所 > 中国科学院成都生物研究所 > 生物多样性与生态系统服务领域 > 中国科学院山地生态恢复与生物资源利用重点实验室

	Flavonoids from the seeds of Oroxylum indicum and their anti-inflammatory and cytotoxic activities
	Wu, Bing-Lan 1,3; Wu, Zhou-Wei 1,3; Yang, Fan 1,3; SheN, Xiao-Fei 2; Wang, Lun 1; Chen, Bin 1; Li, Fu 1; Wang, Ming-Kui 1
刊名	PHYTOCHEMISTRY LETTERS
	2019
卷号	32 页码:66-69
关键词	Oroxylum indicum Flavonoid glycosides Anti-inflammatory activity Cytotoxic activity
ISSN号	1874-3900
DOI	10.1016/j.phytol.2019.05.003
产权排序	1
文献子类	Article
英文摘要	Two new flavonoid glycosides, named oroxin C (1) and oroxin D (scutellarein 4'-methyl ether 7-O-beta-D-gluco-pyranosyl-(1 -> 6)beta-D-glucopyranoside, 2), together with eight known flavonoids (3-10), were isolated from the seeds of Oroxylum indicum. Their structures were elucidated unambiguously by spectroscopic techniques and chemical methods. Anti-inflammatory and cytotoxic activities of all the isolated compounds were evaluated. Chrysin (3) and chrysin-6-C-beta-D glucopyranosyl-8-C-alpha-L arabinopyranoside (10) showed moderate inhibitory effects aganist the LPS-induced NO production in murine RAW264.7 macrophages with IC50 values of 18.63 +/- 0.91 and 28.69 +/- 0.43 mu M, respectively. Chrysin (3) exhibited weak cytotoxic activity aganist A549, HepG2 and SW480 human cancer cell lines with IC50 values of 40.88 +/- 3.85, 50.55 +/- 2.59 and 91.60 +/- 4.27 mu M, respectively.
学科主题	Pharmacology & Toxicology
URL标识	查看原文
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000476725000013
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/31081]
专题	生物多样性与生态系统服务领域_中国科学院山地生态恢复与生物资源利用重点实验室
作者单位	1.Chinese Acad Sci, Chengdu Inst Biol, Key Lab Mt Ecol Restorat & Bioresource Utilizat &, Key Lab Sichuan Prov, Chengdu 610041, Sichuan, Peoples R China; 2.Sichuan Univ, West China Second Univ Hosp, Dept Paediat,Minist Educ, Key Lab Birth Defects & Related Dis Women & Child, Chengdu 610041, Sichuan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China;
推荐引用方式 GB/T 7714	Wu, Bing-Lan,Wu, Zhou-Wei,Yang, Fan,et al. Flavonoids from the seeds of Oroxylum indicum and their anti-inflammatory and cytotoxic activities[J]. PHYTOCHEMISTRY LETTERS,2019,32:66-69.
APA	Wu, Bing-Lan.,Wu, Zhou-Wei.,Yang, Fan.,SheN, Xiao-Fei.,Wang, Lun.,...&Wang, Ming-Kui.(2019).Flavonoids from the seeds of Oroxylum indicum and their anti-inflammatory and cytotoxic activities.PHYTOCHEMISTRY LETTERS,32,66-69.
MLA	Wu, Bing-Lan,et al."Flavonoids from the seeds of Oroxylum indicum and their anti-inflammatory and cytotoxic activities".PHYTOCHEMISTRY LETTERS 32(2019):66-69.