Poly(cystine-PCL) based pH/redox dual-responsive nanocarriers for enhanced tumor therapy

doi:10.1039/c9bm00009g

CORC > 成都生物研究所 > 中国科学院成都生物研究所 > 生物多样性与生态系统服务领域 > 中国科学院山地生态恢复与生物资源利用重点实验室

	Poly(cystine-PCL) based pH/redox dual-responsive nanocarriers for enhanced tumor therapy
	Zhang, Xinyu 1; Kang, Yang 2; Liu, Gui-ting 1; Li, Dan-dan 1; Zhang, Jia-yuan 3; Gu, Zhi-peng 1; Wu, Jun 1
刊名	BIOMATERIALS SCIENCE
	2019
卷号	7 期号:5 页码:1962-1972
ISSN号	2047-4830
DOI	10.1039/c9bm00009g
产权排序	2
文献子类	Article
英文摘要	Functional polymeric drug delivery systems have generated enormous interest due to their excellent features. This paper reports the development of a novel pH and redox dual-sensitive polymer for anticancer paclitaxel (PTX) delivery applications. The polymer was prepared by polycondensation of disulfide bond-containing dimethyl l-cystinate (Cys) and polycaprolactone (PCL) oligomer via a pH-responsive imine bond. Using the nanoprecipitation method, the polymer can be formulated as nanoparticles (poly(Cys-PCL)/PTX NPs) with a diameter less than 100 nm, as measured by TEM and DLS. The NPs release PTX significantly faster at mildly acidic pH and high concentrations of GSH, exhibiting almost no burst release under the physiological conditions of plasma. Notably, the NPs efficiently deliver PTX to the tumor cells, which was more cytotoxic to 4T1 cancer cells than the pure PTX alone. In vivo results reveal an excellent tumor inhibiting ability, good drug tolerability and biosafety of poly(Cys-PCL)/PTX NPs. Overall, the poly(Cys-PCL)/PTX NPs platform may have greater potential in enhancing cancer therapy.
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WOS关键词	DRUG-DELIVERY ; MICELLES ; NANOPARTICLES ; CHEMOTHERAPY ; PRODRUG ; PH ; NANOPLATFORM ; RESISTANCE
WOS研究方向	Materials Science
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000466769000016
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/30541]
专题	生物多样性与生态系统服务领域_中国科学院山地生态恢复与生物资源利用重点实验室
通讯作者	Wu, Jun
作者单位	1.Sun Yat Sen Univ, Sch Biomed Engn, Key Lab Sensing Technol & Biomed Instrument Guang, Guangzhou 510006, Guangdong, Peoples R China; 2.Chinese Acad Sci, Key Lab Mt Ecol Restorat & Bioresource Utilizat, Chengdu Inst Biol, Chengdu 610041, Sichuan, Peoples R China; 3.True Light Middle Sch Guangzhou, Guangzhou 510380, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Xinyu,Kang, Yang,Liu, Gui-ting,et al. Poly(cystine-PCL) based pH/redox dual-responsive nanocarriers for enhanced tumor therapy[J]. BIOMATERIALS SCIENCE,2019,7(5):1962-1972.
APA	Zhang, Xinyu.,Kang, Yang.,Liu, Gui-ting.,Li, Dan-dan.,Zhang, Jia-yuan.,...&Wu, Jun.(2019).Poly(cystine-PCL) based pH/redox dual-responsive nanocarriers for enhanced tumor therapy.BIOMATERIALS SCIENCE,7(5),1962-1972.
MLA	Zhang, Xinyu,et al."Poly(cystine-PCL) based pH/redox dual-responsive nanocarriers for enhanced tumor therapy".BIOMATERIALS SCIENCE 7.5(2019):1962-1972.