Heat stress alters genome-wide profiles of circular RNAs in Arabidopsis

doi:10.1007/s11103-017-0684-7

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	Heat stress alters genome-wide profiles of circular RNAs in Arabidopsis
	Pan, Ting 1,2,3; Sun, Xiuqiang 1,3; Liu, Yangxuan 1,3; Li, Hui 3; Deng, Guangbin 3; Lin, Honghui 2; Wang, Songhu 1,3
刊名	PLANT MOLECULAR BIOLOGY
	2018-02-01
卷号	96 期号:3 页码:217-229
关键词	Heat stress Plant circRNAs Biogenesis CircRNA-mediated ceRNA network
ISSN号	0167-4412
DOI	10.1007/s11103-017-0684-7
产权排序	1
文献子类	Article
英文摘要	1599 novel circRNAs and 1583 heat stress-specific circRNAs were identified in Arabidopsis. Heat stress enhanced accumulation of circRNAs remarkably. Heat stress altered the sizes of circRNAs, numbers of circularized exons and alterative circularization events. A putative circRNA-mediated ceRNA networks under heat stress was established. Heat stress retards plant growth and destabilizes crop yield. The noncoding RNAs were demonstrated to be involved in plant response to heat stress. As a newly-characterized class of noncoding RNAs, circular RNAs (circRNAs) play important roles in transcriptional and post-transcriptional regulation. A few recent investigations indicated that plant circRNAs were differentially expressed under abiotic stress. However, little is known about how heat stress mediates biogenesis of circRNAs in plants. Here, we uncovered 1599 previously-unknown circRNAs and 1583 heat-specific circRNAs, by RNA-sequencing and bioinformatic analysis. Our results indicated that much more circRNAs were expressed under heat stress than in control condition. Besides, heat stress also increased the length of circRNAs, the quantity of circularized exons, and alternative circularization events. Moreover, we observed a positive correlation between expression patterns of some circRNAs and their parental genes. The prediction of ceRNA (competing endogenous RNA) networks indicated that differentially-expressed circRNAs could influence expression of many important genes, that participate in response to heat stress, hydrogen peroxide, and phytohormone signaling pathways, by interacting with the corresponding microRNAs. Together, our observations indicated that heat stress had great impacts on the biogenesis of circRNAs. Heat-induced circRNAs might participate in plant response to heat stress through the circRNA-mediated ceRNA networks.
学科主题	Plant Sciences
URL标识	查看原文
WOS关键词	EXON CIRCULARIZATION ; SIRNA BIOGENESIS ; TRANSCRIPTION ; EXPRESSION ; THALIANA ; CIRCRNAS ; NETWORK ; PATHWAY ; PLANTS ; CERNA
WOS研究方向	Biochemistry & Molecular Biology ; Plant Sciences
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000425617300001
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/30339]
专题	成都生物研究所_农业生物技术研究
作者单位	1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Sichuan Univ, Coll Life Sci, Key Lab Bioresource & Ecoenvironm, State Key Lab Hydraul & Mt River Engn,Minist Educ, Chengdu 610064, Sichuan, Peoples R China; 3.Chinese Acad Sci, Chengdu Inst Biol, CAS Ctr Excellence Mol Plant Sci, Chengdu 610041, Sichuan, Peoples R China;
推荐引用方式 GB/T 7714	Pan, Ting,Sun, Xiuqiang,Liu, Yangxuan,et al. Heat stress alters genome-wide profiles of circular RNAs in Arabidopsis[J]. PLANT MOLECULAR BIOLOGY,2018,96(3):217-229.
APA	Pan, Ting.,Sun, Xiuqiang.,Liu, Yangxuan.,Li, Hui.,Deng, Guangbin.,...&Wang, Songhu.(2018).Heat stress alters genome-wide profiles of circular RNAs in Arabidopsis.PLANT MOLECULAR BIOLOGY,96(3),217-229.
MLA	Pan, Ting,et al."Heat stress alters genome-wide profiles of circular RNAs in Arabidopsis".PLANT MOLECULAR BIOLOGY 96.3(2018):217-229.