Tetrabromobisphenol A induced reproductive endocrine-disrupting effects in mussel Mytilus galloprovincialis

doi:10.1016/j.jhazmat.2021.126228

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 中科院海岸带环境过程与生态修复重点实验室 > 近岸生态与环境实验室

	Tetrabromobisphenol A induced reproductive endocrine-disrupting effects in mussel Mytilus galloprovincialis
	Wang, Shuang 1; Ji, Chenglong 1,2,3; Li, Fei 1,3; Zhan, Junfei 1,4; Sun, Tao 1,4; Tang, Jianhui 1,3; Wu, Huifeng 1,2,3
刊名	JOURNAL OF HAZARDOUS MATERIALS
	2021-08-15
卷号	416 页码:9
关键词	Brominated flame retardants Marine invertebrates Endocrine disruptor Steroids sulfonation
ISSN号	0304-3894
DOI	10.1016/j.jhazmat.2021.126228
通讯作者	Ji, Chenglong(clji@yic.ac.cn) ; Wu, Huifeng(hfwu@yic.ac.cn)
英文摘要	Tetrabromobisphenol A (TBBPA) pollution in marine environmental media poses great risks to marine organisms due to its potential endocrine-disrupting effects. However, limited attention of TBBPA's endocrine-disrupting effects has been paid on marine invertebrates. In this work, the reproductive endocrine-disrupting effects of TBBPA were evaluated by observing the gametes development, quantifying the gender-specific gene expression, and determining vertebrate sex hormones in mussels Mytilus galloprovincialis treated with TBBPA for 30 days. Additionally, transcriptomic profiling and enzymes activities were conducted to investigate the potential mechanisms of reproductive endocrine-disrupting effects. We found that promotion of gametogenesis and alterations of vertebrate sex hormones occurred in TBBPA-treated mussels of both sexes. Meanwhile, estrogen sulfotransferase (SULT1E1) and steroid sulfatase (STS) were up-regulated at transcript level as a result of TBBPA treatments, suggesting that TBBPA disrupted the steroidogenesis in mussels through promoting steroids sulfo-nation and hydrolysis of sulfate steroids. The induction of SULTs for TBBPA biotransformation might be responsible for the dysregulation of steroidogenesis and steroids metabolism. Overall, these findings provide a new insight into assessing impact of TBBPA as well as TBBPA biomonitoring in marine environment.
资助项目	National Natural Science Foundation of China[41976152] ; Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences[YIC_Y855011023] ; Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences[Y855011024] ; Youth Innovation Promotion Association CAS[2017255] ; Yantai Science and Technology Development Plan[2020MSGY060]
WOS关键词	GENDER-SPECIFIC RESPONSES ; SCALLOP CHLAMYS-FARRERI ; TESTOSTERONE CONCENTRATIONS ; BISPHENOL-A ; TBBPA ; ESTRADIOL-17-BETA ; SEX ; GAMETOGENESIS ; GLUCURONIDE ; SULFATASE
WOS研究方向	Engineering ; Environmental Sciences & Ecology
语种	英语
WOS记录号	WOS:000664769200005
资助机构	National Natural Science Foundation of China ; Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences ; Youth Innovation Promotion Association CAS ; Yantai Science and Technology Development Plan
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/29458]
专题	烟台海岸带研究所_近岸生态与环境实验室烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
通讯作者	Ji, Chenglong; Wu, Huifeng
作者单位	1.Chinese Acad Sci, Shandong Key Lab Coastal Environm Processes, CAS Key Lab Coastal Environm Processes & Ecol Rem, Yantai Inst Coastal Zone Res,YICCAS, Yantai 264003, Peoples R China 2.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 26071, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wang, Shuang,Ji, Chenglong,Li, Fei,et al. Tetrabromobisphenol A induced reproductive endocrine-disrupting effects in mussel Mytilus galloprovincialis[J]. JOURNAL OF HAZARDOUS MATERIALS,2021,416:9.
APA	Wang, Shuang.,Ji, Chenglong.,Li, Fei.,Zhan, Junfei.,Sun, Tao.,...&Wu, Huifeng.(2021).Tetrabromobisphenol A induced reproductive endocrine-disrupting effects in mussel Mytilus galloprovincialis.JOURNAL OF HAZARDOUS MATERIALS,416,9.
MLA	Wang, Shuang,et al."Tetrabromobisphenol A induced reproductive endocrine-disrupting effects in mussel Mytilus galloprovincialis".JOURNAL OF HAZARDOUS MATERIALS 416(2021):9.