Memory Deficit in Patients With Temporal Lobe Epilepsy: Evidence From Eye Tracking Technology | |
Zhu, Guangpu4,5,6; Wang, Jing3; Xiao, Ling3; Yang, Ke3; Huang, Kailing3; Li, Beibin3; Huang, Sha3; Hu, Bingliang4; Xiao, Bo3; Liu, Ding1 | |
刊名 | FRONTIERS IN NEUROSCIENCE |
2021-09-07 | |
卷号 | 15 |
关键词 | eye tracking memory impairment temporal lobe epilepsy electroencephalography visual attention |
ISSN号 | 1662-453X |
DOI | 10.3389/fnins.2021.716476 |
产权排序 | 1 |
英文摘要 | Objective: To explore quantitative measurements of the visual attention and neuroelectrophysiological relevance of memory deficits in temporal lobe epilepsy (TLE) by eye tracking and electroencephalography (EEG).
Methods: Thirty-four TLE patients and twenty-eight healthy controls were invited to complete neurobehavioral assessments, cognitive oculomotor tasks, and 24-h video EEG (VEEG) recordings using an automated computer-based memory assessment platform with an eye tracker. Visit counts, visit time, and time of first fixation on areas of interest (AOIs) were recorded and analyzed in combination with interictal epileptic discharge (IED) characteristics from the bilateral temporal lobes.
Results: The TLE patients had significantly worse Wechsler Digit Span scores [F(1, 58) = 7.49, p = 0.008]. In the Short-Term Memory Game with eye tracking, TLE patients took a longer time to find the memorized items [F(1, 57) = 17.30, p < 0.001]. They had longer first fixation [F(1, 57) = 4.06, p = 0.049] and more visit counts [F(1, 57) = 7.58, p = 0.008] on the target during the recall. Furthermore, the performance of the patients in the Digit Span task was negatively correlated with the total number of IEDs [r(28) = -0.463, p = 0.013] and the number of spikes per sleep cycle [r(28) = -0.420, p = 0.026].
Conclusion: Eye tracking appears to be a quantitative, objective measure of memory evaluation, demonstrating memory retrieval deficits but preserved visual attention in TLE patients. Nocturnal temporal lobe IEDs are closely associated with memory performance, which might be the electrophysiological mechanism for memory impairment in TLE.
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语种 | 英语 |
出版者 | FRONTIERS MEDIA SA |
WOS记录号 | WOS:000697387900001 |
内容类型 | 期刊论文 |
源URL | [http://ir.opt.ac.cn/handle/181661/95074] |
专题 | 西安光学精密机械研究所_光学影像学习与分析中心 |
通讯作者 | Feng, Li; Wang, Quan |
作者单位 | 1.Cent South Univ, Xiangya Hosp 3, Dept Neurol, Changsha, Peoples R China 2.Univ Washington, Paul G Allen Sch Comp Sci & Engn, Seattle, WA 98195 USA 3.Cent South Univ, Dept Neurol, Xiangya Hosp, Changsha, Peoples R China 4.Chinese Acad Sci, Xian Inst Opt & Precis Mech, Key Lab Biomed Spect Xian, Xian, Peoples R China 5.Univ Chinese Acad Sci, Beijing, Peoples R China 6.Chinese Acad Sci, Key Lab Spectral Imaging Technol, Xian Inst Opt & Precis Mech, Xian, Peoples R China |
推荐引用方式 GB/T 7714 | Zhu, Guangpu,Wang, Jing,Xiao, Ling,et al. Memory Deficit in Patients With Temporal Lobe Epilepsy: Evidence From Eye Tracking Technology[J]. FRONTIERS IN NEUROSCIENCE,2021,15. |
APA | Zhu, Guangpu.,Wang, Jing.,Xiao, Ling.,Yang, Ke.,Huang, Kailing.,...&Wang, Quan.(2021).Memory Deficit in Patients With Temporal Lobe Epilepsy: Evidence From Eye Tracking Technology.FRONTIERS IN NEUROSCIENCE,15. |
MLA | Zhu, Guangpu,et al."Memory Deficit in Patients With Temporal Lobe Epilepsy: Evidence From Eye Tracking Technology".FRONTIERS IN NEUROSCIENCE 15(2021). |
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