Estimating the accumulative dose uncertainty for intracavitary and interstitial brachytherapy

doi:10.1186/s12938-021-00942-z

	Estimating the accumulative dose uncertainty for intracavitary and interstitial brachytherapy
	Wang, Binbing 1; Hu, Weibiao 2; Shan, Guoping 1; Xu, Xiaoxian 1
刊名	BIOMEDICAL ENGINEERING ONLINE
	2021-10-18
卷号	20
关键词	Accumulative dose Intracavitary brachytherapy Interstitial brachytherapy Deformable registration
DOI	10.1186/s12938-021-00942-z
通讯作者	Xu, Xiaoxian(xuxx@zjcc.org.cn)
英文摘要	Background Image-guided adaptive brachytherapy shows the ability to deliver high doses to tumors while sparing normal tissues. However, interfraction dose delivery introduces uncertainties to high dose estimation, which relates to normal tissue toxicity. The purpose of this study was to investigate the high-dose regions of two applicator approaches in brachytherapy. Method For 32 cervical cancer patients, the CT images from each fraction were wrapped to a reference image, and the displacement vector field (DVF) was calculated with a hybrid intensity-based deformable registration algorithm. The fractional dose was then accumulated to calculate the position and the overlap of high dose (D2cc) during multiple fractions. Result The overall Dice similarity coefficient (DSC) of the deformation algorithm for the bladder and the rectum was (0.97 and 0.91). No significant difference was observed between the two applicators. However, the location of the intracavitary brachytherapy (ICBT) high-dose region was relatively concentrated. The overlap volume of bladder and rectum D2cc was 0.42 and 0.71, respectively, which was higher than that of interstitial brachytherapy (ISBT) (0.26 and 0.31). The cumulative dose was overestimated in ISBT cases when using the GEC-recommended method. The ratio of bladder and rectum D2cc to the GEC method was 0.99 and 1, respectively, which was higher than that of the ISBT method (0.96 and 0.94). Conclusion High-dose regions for brachytherapy based on different applicator types were different. The 3D-printed ICBT has better high-dose region consistency than freehand ISBT and hence is more predictable.
资助项目	Natural Science Foundation of Zhejiang Province[LSY19H180002] ; Zhejiang Province Key Research and Development Program[2019C03003] ; Medical Science and Technology Program of Zhejiang Province[2021PY039] ; Medical Science and Technology Program of Zhejiang Province[2021KY083] ; National Natural Science Foundation of China[12005190]
WOS关键词	DEFORMABLE IMAGE REGISTRATION ; CERVIX CANCER BRACHYTHERAPY ; SEGMENTATION ; ALGORITHM ; BLADDER ; ORGAN ; PARAMETERS ; ACCURACY ; HEAD
WOS研究方向	Engineering
语种	英语
出版者	BMC
WOS记录号	WOS:000708455500001
资助机构	Natural Science Foundation of Zhejiang Province ; Zhejiang Province Key Research and Development Program ; Medical Science and Technology Program of Zhejiang Province ; National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/125599]
专题	中国科学院合肥物质科学研究院
通讯作者	Xu, Xiaoxian
作者单位	1.Chinese Acad Sci, Zhejiang Key Lab Radiat Oncol, Inst Basic Med & Canc IBMC,Zhejiang Canc Hosp, Dept Radiat Phys,Canc Hosp,Univ Chinese Acad Sci, 1 East Banshan Rd, Hangzhou 310022, Zhejiang, Peoples R China 2.Taizhou Hosp Zhejiang Prov, Taizhou 318000, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Wang, Binbing,Hu, Weibiao,Shan, Guoping,et al. Estimating the accumulative dose uncertainty for intracavitary and interstitial brachytherapy[J]. BIOMEDICAL ENGINEERING ONLINE,2021,20.
APA	Wang, Binbing,Hu, Weibiao,Shan, Guoping,&Xu, Xiaoxian.(2021).Estimating the accumulative dose uncertainty for intracavitary and interstitial brachytherapy.BIOMEDICAL ENGINEERING ONLINE,20.
MLA	Wang, Binbing,et al."Estimating the accumulative dose uncertainty for intracavitary and interstitial brachytherapy".BIOMEDICAL ENGINEERING ONLINE 20(2021).