Combined biological effects of silver nanoparticles and heavy metals in different target cell lines

doi:10.1007/s11356-021-16395-9

	Combined biological effects of silver nanoparticles and heavy metals in different target cell lines
	Wang, Xue 1,2; Xu, An 1,2,3; Liu, Yun 2
刊名	ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
	2021-10-14
关键词	Silver nanoparticles (AgNPs) Heavy metals Co-effects Target cell lines
ISSN号	0944-1344
DOI	10.1007/s11356-021-16395-9
通讯作者	Liu, Yun(yliu@itb.ac.cn)
英文摘要	Silver nanoparticles (AgNPs) and heavy metals are considered to coexist in the environment. Increasing evidence shows that AgNPs can interact with heavy metals; however, the impact of distinct exposure conditions on their combined toxicity is still largely unknown. Here, we investigated the co-effects of AgNPs and heavy metals, including arsenic (As), cadmium (Cd), and nickel (Ni), in target cell lines. The results demonstrated that pretreated with polyvinylpyrrolidone-coated (PVP-coated) AgNPs at noncytotoxic concentrations significantly inhibited the cytotoxicity of As and Cd in human-hamster hybrid A(L) cells, but had slight effect on the toxicity of Ni. The antagonistic effects have also been observed in other non-cancerous cell lines, such as Chinese hamster ovary (CHO) cells, mouse embryonic fibroblasts (MEFs), and human normal liver (LO2) cells. In addition, the co-effects between AgNPs and heavy metals are independent of surface coatings of AgNPs. Our data revealed that the combined biological effects of AgNPs and heavy metals are closely related to the physicochemical properties of heavy metals themselves and the tested cell lines.
资助项目	National Natural Science Foundation of China[22076191] ; National Natural Science Foundation of China[21677147] ; National Natural Science Foundation of China[91743106] ; Youth Innovation Promotion Association of CAS[2020444] ; Anhui Provincial Key RD Programs[202004i07020015] ; Dean's Fund of Hefei Institute of Physical Science[YZJJZX202014] ; Opening Foundation of Anhui Province of Key Laboratory of Environmental Toxicology and Pollution Control Technology[Y79AH72588]
WOS关键词	OXIDATIVE STRESS ; CYTOTOXICITY ; TOXICITY ; ANTIBACTERIAL ; AUTOPHAGY ; EXPOSURE ; CITRATE
WOS研究方向	Environmental Sciences & Ecology
语种	英语
出版者	SPRINGER HEIDELBERG
WOS记录号	WOS:000707311800001
资助机构	National Natural Science Foundation of China ; Youth Innovation Promotion Association of CAS ; Anhui Provincial Key RD Programs ; Dean's Fund of Hefei Institute of Physical Science ; Opening Foundation of Anhui Province of Key Laboratory of Environmental Toxicology and Pollution Control Technology
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/125555]
专题	中国科学院合肥物质科学研究院
通讯作者	Liu, Yun
作者单位	1.Univ Sci & Technol China, Sch Environm Sci & Optoelect Technol, Hefei 230026, Anhui, Peoples R China 2.Chinese Acad Sci, Hefei Inst Phys Sci, Anhui Lab High Magnet Field, Anhui Prov Key Lab Environm Toxicol & Pollut Cont, Hefei 230031, Anhui, Peoples R China 3.Anhui Univ, Inst Phys Sci & Informat Technol, Hefei 230601, Anhui, Peoples R China
推荐引用方式 GB/T 7714	Wang, Xue,Xu, An,Liu, Yun. Combined biological effects of silver nanoparticles and heavy metals in different target cell lines[J]. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,2021.
APA	Wang, Xue,Xu, An,&Liu, Yun.(2021).Combined biological effects of silver nanoparticles and heavy metals in different target cell lines.ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH.
MLA	Wang, Xue,et al."Combined biological effects of silver nanoparticles and heavy metals in different target cell lines".ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2021).