General Surface-Enhanced Raman Spectroscopy Method for Actively Capturing Target Molecules in Small Gaps

doi:10.1021/jacs.1c02169

	General Surface-Enhanced Raman Spectroscopy Method for Actively Capturing Target Molecules in Small Gaps
	Ge, Meihong 2,3; Li, Pan 1,2; Zhou, Guoliang 2,3; Chen, Siyu 2,3; Han, Wei 1,2; Qin, Feng 2,3; Nie, Yuman 5; Wang, Yaoxiong 5; Qin, Miao 2,3; Huang, Guangyao 2,3
刊名	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
	2021-05-26
卷号	143
ISSN号	0002-7863
DOI	10.1021/jacs.1c02169
通讯作者	Yang, Liangbao(lbyang@iim.ac.cn)
英文摘要	Over the past decade, many efforts have been devoted to designing and fabricating substrates for surface-enhanced Raman spectroscopy (SERS) with abundant hot spots to improve the sensitivity of detection. However, there have been many difficulties involved in causing molecules to enter hot spots actively or effectively. Here, we report a general SERS method for actively capturing target molecules in small gaps (hot spots) by constructing a nanocapillary pumping model. The ubiquity of hot spots and the inevitability of molecules entering them lights up all the hot spots and makes them effective. This general method can realize the highly sensitive detection of different types of molecules, including organic pollutants, drugs, poisons, toxins, pesticide residues, dyes, antibiotics, amino acids, antitumor drugs, explosives, and plasticizers. Additionally, in the dynamic detection process, an efficient and stable signal can be maintained for 1-2 min, which increases the practicality and operability of this method. Moreover, a dynamic detection process like this corresponds to the processes of material transformation in some organisms, so the method can be used to monitor transformation processes such as the death of a single cell caused by photothermal stimulation. Our method provides a novel pathway for generating hot spots that actively attract target molecules, and it can achieve general ultratrace detection of diverse substances and be applied to the study of cell behaviors in biological systems.
资助项目	National Major Scientific and Technological Special Project for Significant New Drugs Development[2018ZX09J18112] ; National Science Foundation of China[61605221] ; National Natural Science Foundation of China[21974142] ; Nature Science Research Project of Anhui Province[1908085QB65] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA22040303]
WOS关键词	GOLD NANOPARTICLES ; HOT-SPOTS ; SERS ; SCATTERING ; DIFFERENTIATION ; GROWTH ; ARRAYS ; DRUGS ; WATER
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000657212800023
资助机构	National Major Scientific and Technological Special Project for Significant New Drugs Development ; National Science Foundation of China ; National Natural Science Foundation of China ; Nature Science Research Project of Anhui Province ; Strategic Priority Research Program of the Chinese Academy of Sciences
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/123656]
专题	中国科学院合肥物质科学研究院
通讯作者	Yang, Liangbao
作者单位	1.Chinese Acad Sci, Hefei Canc Hosp, Dept Pharm, Hefei 230031, Anhui, Peoples R China 2.Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Hefei 230031, Anhui, Peoples R China 3.Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China 4.Xiamen Univ, State Key Lab Phys Chem Solid Surfaces, Xiamen 361005, Fujian, Peoples R China 5.Chinese Acad Sci, Inst Intelligent Machines, Hefei Inst Phys Sci, Hefei 230031, Anhui, Peoples R China
推荐引用方式 GB/T 7714	Ge, Meihong,Li, Pan,Zhou, Guoliang,et al. General Surface-Enhanced Raman Spectroscopy Method for Actively Capturing Target Molecules in Small Gaps[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2021,143.
APA	Ge, Meihong.,Li, Pan.,Zhou, Guoliang.,Chen, Siyu.,Han, Wei.,...&Tian, Zhongqun.(2021).General Surface-Enhanced Raman Spectroscopy Method for Actively Capturing Target Molecules in Small Gaps.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,143.
MLA	Ge, Meihong,et al."General Surface-Enhanced Raman Spectroscopy Method for Actively Capturing Target Molecules in Small Gaps".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 143(2021).