Association of advanced glycation end products with diabetic retinopathy in type 2 diabetes mellitus

doi:10.1016/j.diabres.2021.108880

	Association of advanced glycation end products with diabetic retinopathy in type 2 diabetes mellitus
	Ying, Lingwen 1,2; Shen, Yun 1,2; Zhang, Yang 3,4; Wang, Yikun 3; Liu, Yong 3; Yin, Jun 1,2; Wang, Yufei 1,2; Yin, Jingrong 1,2; Zhu, Wei 1,2; Bao, Yuqian 1,2
刊名	DIABETES RESEARCH AND CLINICAL PRACTICE
	2021-07-01
卷号	177
关键词	Diabetic retinopathy Advanced glycation end products Non-invasive Type 2 diabetes
ISSN号	0168-8227
DOI	10.1016/j.diabres.2021.108880
通讯作者	Wang, Yikun(wyk@aiofm.ac.cn) ; Zhou, Jian(zhoujian@sjtu.edu.cn)
英文摘要	Aims: Advanced glycation end products (AGEs) were reported to be associated with diabetes development and diabetes related complications when accumulated in high levels. This study investigated the association between AGEs and diabetic retinopathy (DR). Methods: A total of 1,471 patients with type 2 diabetes were enrolled. Fundus radiography was used for DR measurement. AGEs were detected through non-invasive skin autofluorescence method. Results: Patients with more advanced DR showed a much higher AGEs, and the prevalence of DR (based on the severity) increase with ascending AGEs quartiles (all P for trend < 0.001). The multivariable-adjusted odds ratios of any DR across AGEs quartiles were 1.00, 1.69 (95% confidence interval [CI] 1.16-2.47), 1.58 (95%CI 1.06-2.37) and 1.60 (95%CI 1.05-2.44) (P for trend = 0.044), respectively. Similar results were found in vision-threatening DR (VTDR) subgroup (P for trend = 0.009). When AGEs was considered as a continuous variable by using restricted cubic splines, a graded positive association of AGEs with the odds of any presence of DR was observed (P for trend < 0.001). Further, we found that AGEs presented the similar predictive value for any DR with glycated hemoglobin A(1c) (HbA(1c)). When it comes to VTDR, AGEs showed a significantly higher efficacy in early screening than HbA(1c) (P = 0.002). With a cut-off point of 77.1, the sensitivity, specificity and area under the curve of AGEs were 90.0% (95%CI 76.3-97.2%), 49.4% (95%CI 46.8-52.0%), and 0.728 (95%CI 0.704-0.750), respectively. Conclusion: Non-invasive measured skin AGEs, associated with the prevalence of all stages of DR, might be a more suitable indicator than HbA(1c) for mimicking the poor prognosis of hyperglycemia. (C) 2021 Elsevier B.V. All rights reserved.
资助项目	National Key R&D Program of China[2018YFC2000802] ; Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support[20161430] ; Bureau of International Cooperation, Chinese Academy of Sciences[116134KYSB20170018] ; Key Research and Development Program of Anhui Province of China[1804b06020350]
WOS关键词	SKIN AUTOFLUORESCENCE
WOS研究方向	Endocrinology & Metabolism
语种	英语
出版者	ELSEVIER IRELAND LTD
WOS记录号	WOS:000680513200035
资助机构	National Key R&D Program of China ; Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support ; Bureau of International Cooperation, Chinese Academy of Sciences ; Key Research and Development Program of Anhui Province of China
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/123111]
专题	中国科学院合肥物质科学研究院
通讯作者	Wang, Yikun; Zhou, Jian
作者单位	1.Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Shanghai Clin Ctr Diabet, Dept Endocrinol & Metab, Shanghai 200233, Peoples R China 2.Shanghai Diabet Inst, Shanghai Key Lab Diabet Mellitus, Shanghai 200233, Peoples R China 3.Chinese Acad Sci, Anhui Inst Opt & Fine Mech, Hefei Inst Phys Sci, 350 Shushanhu Rd, Hefei 230031, Anhui, Peoples R China 4.Univ Sci & Technol China, Hefei 230026, Peoples R China
推荐引用方式 GB/T 7714	Ying, Lingwen,Shen, Yun,Zhang, Yang,et al. Association of advanced glycation end products with diabetic retinopathy in type 2 diabetes mellitus[J]. DIABETES RESEARCH AND CLINICAL PRACTICE,2021,177.
APA	Ying, Lingwen.,Shen, Yun.,Zhang, Yang.,Wang, Yikun.,Liu, Yong.,...&Zhou, Jian.(2021).Association of advanced glycation end products with diabetic retinopathy in type 2 diabetes mellitus.DIABETES RESEARCH AND CLINICAL PRACTICE,177.
MLA	Ying, Lingwen,et al."Association of advanced glycation end products with diabetic retinopathy in type 2 diabetes mellitus".DIABETES RESEARCH AND CLINICAL PRACTICE 177(2021).