Interplay of Nanoparticle Properties during Endocytosis

doi:10.3390/cryst11070728

CORC > 力学研究所 > 中国科学院力学研究所 > 非线性力学国家重点实验室

	Interplay of Nanoparticle Properties during Endocytosis
	Wang XH(王小环)1,2,3; Li L(李龙)2,3; Song F(宋凡)1,2,3
刊名	CRYSTALS
	2021-07-01
卷号	11 期号:7 页码:13
关键词	nanoparticle endocytosis nanoparticle properties
DOI	10.3390/cryst11070728
通讯作者	Li, Long(lilong@lnm.imech.ac.cn)
英文摘要	Nanoparticles (NPs) have been widely applied as drug carriers in drug delivery, due to their unique physical and structural properties. To achieve the drug delivery purpose, receptor-mediated endocytosis is a primary explored mechanism to internalize NPs into tumor cells. During the endocytosis process, properties of NPs, including size, shape, and surface functionality, play an important role in determining the final drug delivery efficacy. Many of these NP properties have been extensively explored individually. However, the multiple NP properties naturally interplay with each other in the endocytosis process to determine the internalization efficiency together. Therefore, it is significantly important to understand the interplay of different NP properties to improve the NP's final delivery efficacy. In this review, we focus on the interplay of NPs properties on the endocytosis process to summarize the relevant experimental observations and physical mechanisms. Particularly, three different aspects are discussed in detail, including the interplay between size and shape; size and elasticity; shape and elasticity. We have summarized the most recent works and highlighted that building up systematic understandings for the complex interplay between NP properties can greatly help a better design of NP platforms for drug delivery.
分类号	二类
资助项目	NSFC Basic Science Center Program[11988102] ; Youth Innovation Promotion Association CAS ; National Natural Science Foundation of China[11902327] ; National Natural Science Foundation of China[11972041] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB22040102]
WOS关键词	RECEPTOR-LIGAND BINDING ; CELLULAR UPTAKE ; DRUG-DELIVERY ; PEGYLATED NANOPARTICLES ; SURFACE-CHEMISTRY ; SIZE ; SHAPE ; STIFFNESS ; PENETRATION ; PHARMACOKINETICS
WOS研究方向	Crystallography ; Materials Science
语种	英语
WOS记录号	WOS:000676577300001
资助机构	NSFC Basic Science Center Program ; Youth Innovation Promotion Association CAS ; National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences
其他责任者	Li, Long
内容类型	期刊论文
源URL	[http://dspace.imech.ac.cn/handle/311007/87074]
专题	力学研究所_非线性力学国家重点实验室
作者单位	1.Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, Beijing 100190, Peoples R China; 3.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China;
推荐引用方式 GB/T 7714	Wang XH,Li L,Song F. Interplay of Nanoparticle Properties during Endocytosis[J]. CRYSTALS,2021,11(7):13.
APA	王小环,李龙,&宋凡.(2021).Interplay of Nanoparticle Properties during Endocytosis.CRYSTALS,11(7),13.
MLA	王小环,et al."Interplay of Nanoparticle Properties during Endocytosis".CRYSTALS 11.7(2021):13.