Eradicating intracellular MRSA via targeted delivery of lysostaphin and vancomycin with mannose-modified exosomes

doi:10.1016/j.jconrel.2020.11.045

	Eradicating intracellular MRSA via targeted delivery of lysostaphin and vancomycin with mannose-modified exosomes
	Yang, Xiaohong 1,2; Xie, Beibei 2; Peng, Haibo 2; Shi, Gongming 2; Sreenivas, Banne 2; Guo, Jian 2; Wang, Chenhui 2; He, Yun 2
刊名	JOURNAL OF CONTROLLED RELEASE
	2021-01-10
卷号	329 页码:454-467
关键词	Exosomes Surface functionalization Antibiotics Targeted delivery Intracellular infection
ISSN号	0168-3659
DOI	10.1016/j.jconrel.2020.11.045
通讯作者	Wang, Chenhui(wangchenhui@cqu.edu.cn) ; He, Yun(yun.he@cqu.edu.cn)
英文摘要	Intracellular methicillin-resistant Staphylococcus aureus (MRSA) is extremely difficult to remove by common antibiotics, leading to infection recurrence and resistance. Herein we report a novel exosome-based antibiotic delivery platform for eradicating intracellular MRSA, where mannosylated exosome (MExos) is employed as the drug carrier and preferentially taken up by macrophages, delivering lysostaphin (MExoL) and vancomycin (MExoV) to intracellular pathogens. Combination of MExoL and MExoV eradicated intracellular quiescent MRSA. Moreover, MExos rapidly accumulated in mouse liver and spleen, the target organs of intracellular MRSA, after intravenous (IV) administration. Thus, the MExos antibiotic delivery platform is a promising strategy for combating intracellular infection.
资助项目	National Natural Science Foundation of China[21572027] ; National Natural Science Foundation of China[81703424] ; Ministry of Science and Technology[2019ZX09301164] ; Chongqing Science and Technology Bureau[csts2019jcyj-zdxmX0021]
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000626334700033
内容类型	期刊论文
源URL	[http://119.78.100.138/handle/2HOD01W0/13329]
专题	中国科学院重庆绿色智能技术研究院
通讯作者	Wang, Chenhui; He, Yun
作者单位	1.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, 266 Fangzheng Ave,Shuitu Technol Dev Zone, Chongqing 400714, Peoples R China 2.Chongqing Univ, Sch Pharmaceut Sci, Chongqing Key Lab Nat Prod Synth & Drug Res, 55 Daxuecheng South Rd, Chongqing 401331, Peoples R China
推荐引用方式 GB/T 7714	Yang, Xiaohong,Xie, Beibei,Peng, Haibo,et al. Eradicating intracellular MRSA via targeted delivery of lysostaphin and vancomycin with mannose-modified exosomes[J]. JOURNAL OF CONTROLLED RELEASE,2021,329:454-467.
APA	Yang, Xiaohong.,Xie, Beibei.,Peng, Haibo.,Shi, Gongming.,Sreenivas, Banne.,...&He, Yun.(2021).Eradicating intracellular MRSA via targeted delivery of lysostaphin and vancomycin with mannose-modified exosomes.JOURNAL OF CONTROLLED RELEASE,329,454-467.
MLA	Yang, Xiaohong,et al."Eradicating intracellular MRSA via targeted delivery of lysostaphin and vancomycin with mannose-modified exosomes".JOURNAL OF CONTROLLED RELEASE 329(2021):454-467.