Role of manganese superoxide dismutase (Mn-SOD) against Cr(III)-induced toxicity in bacteria

doi:10.1016/j.jhazmat.2020.123604

	Role of manganese superoxide dismutase (Mn-SOD) against Cr(III)-induced toxicity in bacteria
	Niu, Aping 3,4; Bian, Wan-Ping 3; Feng, Shuang-Long 3; Pu, Shi-Ya 3,5; Wei, Xing-Yi 1,3; Yang, Yi-Fan 2,3; Song, Li-Yan 3; Pei, De-Sheng 2,3,5
刊名	JOURNAL OF HAZARDOUS MATERIALS
	2021-02-05
卷号	403 页码:10
关键词	Oxidative stress Mn-SOD Morphology variation Cell division Cr species
ISSN号	0304-3894
DOI	10.1016/j.jhazmat.2020.123604
通讯作者	Pei, De-Sheng(peids@cigit.ac.cn)
英文摘要	The toxicity of Cr(VI) was widely investigated, but the defense mechanism against Cr(III) in bacteria are seldom reported. Here, we found that Cr(III) inhibited bacterial growth and induced reactive oxygen species (ROS). After exposure to Cr(III), loss of sodA not only led to the excessive generation of ROS, but also enhanced the level of lipid peroxidation and reduced the GSH level, indicating that the deficiency of Mn-SOD decreased the bacterial resistance ability against Cr(III). The adverse effects of oxidative stress caused by Cr(III) could be recovered by the rescue of Mn-SOD in the sodA-deficient strain. Besides the oxidative stress, Cr(III) could cause the bacterial morphology variation, which was distinct between the wild-type and the sodA-deficient strains due to the differential expressions of Z-ring division genes. Moreover, Mn-SOD might prevent Cr(III) from oxidation on the bacterial surface by combining with Cr(III). Taken together, our results indicated that the Mn-SOD played a vital role in regulating the stress resistance, expression of cell division-related genes, bacterial morphology, and chemistry valence state of Cr. Our findings firstly provided a more in-depth understanding of Cr(III) toxicity and bacterial defense mechanism against Cr(III).
资助项目	CAS Team Project of the Belt and Road ; Three Hundred Leading Talents in Scientific and Technological Innovation Program of Chongqing[CSTCCXLJRC201714] ; National Natural Science Foundation of China[51641907] ; Chongqing Science and Technology Commission[cstc2019jcyj-zdxmX0035] ; Chongqing Science and Technology Commission[cstc2019jcyjmsxm1824] ; Chongqing Science and Technology Commission[2019-04] ; Program of China-Sri Lanka Joint Center for Water Technology Research and Demonstration by the Chinese Academy of Sciences (CAS)/China-Sri Lanka Joint Center for Education and Research by the CAS
WOS研究方向	Engineering ; Environmental Sciences & Ecology
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000596474900003
内容类型	期刊论文
源URL	[http://119.78.100.138/handle/2HOD01W0/12676]
专题	中国科学院重庆绿色智能技术研究院
通讯作者	Pei, De-Sheng
作者单位	1.Chongqing Jiaotong Univ, Sch River & Ocean Engn, Chongqing 400074, Peoples R China 2.Henan Normal Univ, Coll Life Sci, Xinxiang 453007, Henan, Peoples R China 3.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Key Lab Reservoir Aquat Environm, Chongqing 400714, Peoples R China 4.Guizhou Univ, Coll Resources & Environm Engn, Guiyang 550025, Guizhou, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Niu, Aping,Bian, Wan-Ping,Feng, Shuang-Long,et al. Role of manganese superoxide dismutase (Mn-SOD) against Cr(III)-induced toxicity in bacteria[J]. JOURNAL OF HAZARDOUS MATERIALS,2021,403:10.
APA	Niu, Aping.,Bian, Wan-Ping.,Feng, Shuang-Long.,Pu, Shi-Ya.,Wei, Xing-Yi.,...&Pei, De-Sheng.(2021).Role of manganese superoxide dismutase (Mn-SOD) against Cr(III)-induced toxicity in bacteria.JOURNAL OF HAZARDOUS MATERIALS,403,10.
MLA	Niu, Aping,et al."Role of manganese superoxide dismutase (Mn-SOD) against Cr(III)-induced toxicity in bacteria".JOURNAL OF HAZARDOUS MATERIALS 403(2021):10.