Nickel-Catalyzed Asymmetric Addition of Aromatic Halides to Ketones: Highly Enantioselective Synthesis of Chiral 2,3-Dihydrobenzofurans Containing a Tertiary Alcohol | |
Li, Y (Li, Ying)[ 1,2,3,4 ]; Li, WD (Li, Wendian)[ 2,3 ]; Tian, JY (Tian, Jiangyan)[ 2,3 ]; Huang, GZ (Huang, Guozheng)[ 1 ]; Lv, H (Lv, Hui)[ 2,3 ] | |
刊名 | ORGANIC LETTERS |
2020 | |
卷号 | 22期号:14页码:5353-5357 |
ISSN号 | 1523-7060 |
DOI | 10.1021/acs.orglett.0c01612 |
英文摘要 | A highly enantioselective and straightforward synthetic procedure to chiral 3-hydroxy-2,3-dihydrobenzofurans has been developed by nickel/bisoxazoline-catalyzed intramolecular asymmetric addition of aryl halides to unactivated ketones, giving 2,3-dihydrobenzofurans with a chiral tertiary alcohol at the C-3 position in good yields and excellent enantioselectivities (up to 92% yield and 98% ee). The gram-scale reaction also proceeded smoothly without a loss of yield and enantioselectivity. |
WOS记录号 | WOS:000551552600016 |
内容类型 | 期刊论文 |
源URL | [http://ir.xjipc.cas.cn/handle/365002/7395] |
专题 | 新疆理化技术研究所_省部共建新疆特有药用资源利用重点实验室 |
作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Wuhan Univ, Minist Educ, Coll Chem & Mol Sci, Engn Res Ctr Organosilicon Cpds & Mat,Sauvage Ctr, Wuhan 430072, Hubei, Peoples R China 3.Wuhan Univ, Minist Educ, Key Lab Biomed Polymers, Wuhan 430072, Hubei, Peoples R China 4.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Xinjiang, Peoples R China |
推荐引用方式 GB/T 7714 | Li, Y ,Li, WD ,Tian, JY ,et al. Nickel-Catalyzed Asymmetric Addition of Aromatic Halides to Ketones: Highly Enantioselective Synthesis of Chiral 2,3-Dihydrobenzofurans Containing a Tertiary Alcohol[J]. ORGANIC LETTERS,2020,22(14):5353-5357. |
APA | Li, Y ,Li, WD ,Tian, JY ,Huang, GZ ,&Lv, H .(2020).Nickel-Catalyzed Asymmetric Addition of Aromatic Halides to Ketones: Highly Enantioselective Synthesis of Chiral 2,3-Dihydrobenzofurans Containing a Tertiary Alcohol.ORGANIC LETTERS,22(14),5353-5357. |
MLA | Li, Y ,et al."Nickel-Catalyzed Asymmetric Addition of Aromatic Halides to Ketones: Highly Enantioselective Synthesis of Chiral 2,3-Dihydrobenzofurans Containing a Tertiary Alcohol".ORGANIC LETTERS 22.14(2020):5353-5357. |
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