A designed antifungal peptide with therapeutic potential for clinical drug-resistant Candida albicans | |
Wubulikasimu, A (Wubulikasimu, Atikan)[ 1,2 ]; Huang, YT (Huang, Yanting)[ 3 ]; Wali, A (Wali, Ahmidin)[ 1,2 ]; Yili, A (Yili, Abulimiti)[ 1,4 ]; Rong, MQ (Rong, Mingqiang)[ 3 ] | |
刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS |
2020 | |
卷号 | 533期号:3页码:404-409 |
关键词 | Candida albicans Systemic infection Antifungal peptide |
ISSN号 | 0006-291X |
DOI | 10.1016/j.bbrc.2020.08.117 |
英文摘要 | Due to the increasing drug-resistant of Candida albicans (C. albicans), there is an urgent need to develop a novel therapeutic agent for C albicans induced inflammatory disease treatment. Antimicrobial peptides (AMPs) are regarded as one of the most promising antifungal drugs. However, most of the designed AMPs showed side-effects. In the present study, 10 novel peptides were designed based on the sequence of frog skin secretions peptide (Ranacyclin AJ). Among them, AKK8 (RWRFKWWKK) exhibited the strongest antifungal effect against both standard and clinically isolated drug-resistant C. albicans. AKK8 killed C. albicans (within 30 min), and the antifungal effect lasted for 24 h, showed an efficient and long lasted antifungal effect against C. albicans. Notably, AKK8 showed low toxicity to human red blood cells and high stability in human serum. Moreover, AKK8 administration showed therapeutic effects on systemic infections mice induced by the clinical drug-resistant C. albicans, in a dose-depended manner. These findings suggested that AKK8 may be a potential candidate for the anti-inflammation treatments for diseases caused by clinical drug-resistant C. albicans. |
WOS记录号 | WOS:000588268300022 |
内容类型 | 期刊论文 |
源URL | [http://ir.xjipc.cas.cn/handle/365002/7662] |
专题 | 新疆理化技术研究所_资源化学研究室 |
通讯作者 | Yili, A (Yili, Abulimiti)[ 1,4 ] |
作者单位 | 1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China 2.Hunan Normal Univ, Coll Life Sci, Natl & Local Joint Engn Lab Anim Peptide Drug Dev, Changsha 410006, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China 4.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Beijing South Rd 40-1, Urumqi 830011, Peoples R China |
推荐引用方式 GB/T 7714 | Wubulikasimu, A ,Huang, YT ,Wali, A ,et al. A designed antifungal peptide with therapeutic potential for clinical drug-resistant Candida albicans[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2020,533(3):404-409. |
APA | Wubulikasimu, A ,Huang, YT ,Wali, A ,Yili, A ,&Rong, MQ .(2020).A designed antifungal peptide with therapeutic potential for clinical drug-resistant Candida albicans.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,533(3),404-409. |
MLA | Wubulikasimu, A ,et al."A designed antifungal peptide with therapeutic potential for clinical drug-resistant Candida albicans".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 533.3(2020):404-409. |
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