Zebrafish p53 protein enhances the translation of its own mRNA in response to UV irradiation and CPT treatment

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	Zebrafish p53 protein enhances the translation of its own mRNA in response to UV irradiation and CPT treatment
	Zhao, Xiangzhong 1,2; Wu, Ning 1; Ding, Lili 1; Liu, Ming 1; Liu, Haizhou 1; Lin, Xiukun 1,3
刊名	FEBS LETTERS
	2012-04-24
卷号	586 期号:8 页码:1220-1225
关键词	p53 Zebrafish RNA binding protein Translational regulation
ISSN号	0014-5793
通讯作者	Lin, XK (reprint author), Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China.
英文摘要	p53 protein is an important regulatory factor involved in cell growth and development. In our previous study, we demonstrated that recombined zebrafish p53 protein could specifically bind to its own mRNA in vitro. To determine if a similar interaction exists in zebrafish and if this interaction affects zebrafish development, in the present study, we investigated the interaction of p53 protein and its mRNA in zebrafish embryos. Our results revealed that expressed zebrafish p53 protein could bind with its own mRNA in zebrafish embryos. Furthermore, the endogenous activated or ectopically expressed p53 protein could enhance the relative activity of Renilla luciferase fused with p53 3'UTR in response to UV irradiation and CPT treatment, and retarded development of zebrafish embryos was observed. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
学科主题	Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
收录类别	SCI
原文出处	10.1016/j.febslet.2012.03.025
语种	英语
WOS记录号	WOS:000303106100021
公开日期	2013-09-24
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/12407]
专题	海洋研究所_实验海洋生物学重点实验室
作者单位	1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Shandong Acad Med Sci, Inst Basic Med, Key Lab Rare Dis Shandong Prov, Jinan 250062, Peoples R China 3.Beijing Capital Med Univ, Dept Pharmacol, Beijing 100069, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Xiangzhong,Wu, Ning,Ding, Lili,et al. Zebrafish p53 protein enhances the translation of its own mRNA in response to UV irradiation and CPT treatment[J]. FEBS LETTERS,2012,586(8):1220-1225.
APA	Zhao, Xiangzhong,Wu, Ning,Ding, Lili,Liu, Ming,Liu, Haizhou,&Lin, Xiukun.(2012).Zebrafish p53 protein enhances the translation of its own mRNA in response to UV irradiation and CPT treatment.FEBS LETTERS,586(8),1220-1225.
MLA	Zhao, Xiangzhong,et al."Zebrafish p53 protein enhances the translation of its own mRNA in response to UV irradiation and CPT treatment".FEBS LETTERS 586.8(2012):1220-1225.