Evolution of the Cholesterol Biosynthesis Pathway in Animals | |
Zhang, Tingting4,5,10; Yuan, Dongwei4,8,10; Xie, Jun6; Lei, Yongxing1,8; Li, Jianguo9; Fang, Gangqi8,10; Tian, Ling3; Liu, Jiacheng2,8; Cui, Yingying4; Zhang, Min5 | |
刊名 | MOLECULAR BIOLOGY AND EVOLUTION |
2019-11-01 | |
卷号 | 36期号:11页码:2548-2556 |
关键词 | cholesterol biosynthesis pathway gene loss Ediacaran period macroevolution |
ISSN号 | 0737-4038 |
DOI | 10.1093/molbev/msz167 |
英文摘要 | Cholesterol plays essential roles in animal development and disease progression. Here, we characterize the evolutionary pattern of the canonical cholesterol biosynthesis pathway (CBP) in the animal kingdom using both genome-wide analyses and functional experiments. CBP genes in the basal metazoans were inherited from their last common eukaryotic ancestor and evolutionarily conserved for cholesterol biosynthesis. The genomes of both the basal metazoans and deuterostomes retain almost the full set of CBP genes, while Cnidaria and many protostomes have independently experienced multiple massive losses of CBP genes that might be due to the geologic events during the Ediacaran period, such as the appearance of an exogenous sterol supply and the frequent perturbation of ocean oxygenation. Meanwhile, the indispensable utilization processes of cholesterol potentially strengthened the maintenance of the complete set of CBP genes in vertebrates. These results strengthen both biotic and abiotic roles in the macroevolution of a biosynthesis pathway in animals. |
资助项目 | National Science Foundation of China[31620103917] ; National Science Foundation of China[31572325] ; National Science Foundation of China[31501905] ; National Science Foundation of China[31522053] ; Chinese Academy of Sciences[XDB13030700] ; Chinese Academy of Sciences[QYZDB-SSW-SMC029] ; Chinese Academy of Sciences[XDB18000000] ; Chinese Academy of Sciences[XDB27040205] ; Chinese Academy of Sciences[153D31KYSB20160065] ; National Key Research and Development Program of China[2016YFD0101900] ; Postdoctoral Science Foundation of China[2016M591722] |
WOS关键词 | SQUALENE SYNTHASE ; STEROL SYNTHESIS ; TRYPANOSOMA-CRUZI ; LANOSTEROL ; PHYLOGENIES ; FOSSILS ; CLONING ; ORIGIN ; GENOME ; RAFTS |
WOS研究方向 | Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity |
语种 | 英语 |
出版者 | OXFORD UNIV PRESS |
WOS记录号 | WOS:000504091200013 |
资助机构 | National Science Foundation of China ; Chinese Academy of Sciences ; National Key Research and Development Program of China ; Postdoctoral Science Foundation of China |
内容类型 | 期刊论文 |
源URL | [http://ir.nigpas.ac.cn/handle/332004/29731] |
专题 | 中国科学院南京地质古生物研究所 |
通讯作者 | Zhan, Shuai; Li, Sheng |
作者单位 | 1.Chinese Acad Sci, Inst Plant Physiol & Ecol, Key Lab Synthet Biol, Shanghai, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Innovat Ctr Cell Signaling Network, State Key Lab Mol Biol,CAS Ctr Excellence Mol Cel, Shanghai, Peoples R China 3.South China Agr Univ, Guangdong Prov Key Lab Agroanim Genom & Mol Breed, Guangdong Prov Sericulture & Mulberry Engn Res Ct, Coll Anim Sci, Guangzhou, Guangdong, Peoples R China 4.South China Normal Univ, Inst Insect Sci & Technol, Sch Life Sci, Guangdong Prov Key Lab Insect Dev Biol & Appl Tec, Guangzhou, Guangdong, Peoples R China 5.Shanxi Univ, Res Inst Appl Biol, Taiyuan, Shanxi, Peoples R China 6.Fudan Univ, Inst Genet, Sch Life Sci, State Key Lab Genet Engn, Shanghai, Peoples R China 7.Chinese Acad Sci, Nanjing Inst Geol & Palaeontol, State Key Lab Paleobiol & Stratig, Nanjing, Jiangsu, Peoples R China 8.Univ Chinese Acad Sci, Beijing, Peoples R China 9.Shanxi Univ, Inst Biomed Sci, Taiyuan, Shanxi, Peoples R China 10.Chinese Acad Sci, CAS Ctr Excellence Mol Plant Sci, CAS Key Lab Insect Dev & Evolutionary Biol, Inst Plant Physiol & Ecol, Shanghai, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang, Tingting,Yuan, Dongwei,Xie, Jun,et al. Evolution of the Cholesterol Biosynthesis Pathway in Animals[J]. MOLECULAR BIOLOGY AND EVOLUTION,2019,36(11):2548-2556. |
APA | Zhang, Tingting.,Yuan, Dongwei.,Xie, Jun.,Lei, Yongxing.,Li, Jianguo.,...&Li, Sheng.(2019).Evolution of the Cholesterol Biosynthesis Pathway in Animals.MOLECULAR BIOLOGY AND EVOLUTION,36(11),2548-2556. |
MLA | Zhang, Tingting,et al."Evolution of the Cholesterol Biosynthesis Pathway in Animals".MOLECULAR BIOLOGY AND EVOLUTION 36.11(2019):2548-2556. |
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