In vitro studies of deferasirox derivatives as potential organelle-targeting traceable anti-cancer therapeutics

doi:10.1039/d0cc08156f

	In vitro studies of deferasirox derivatives as potential organelle-targeting traceable anti-cancer therapeutics
	Steinbrueck, Axel 1; Sedgwick, Adam C.1; Han, Hai-Hao 2,3; Zhao, Michael Y.1; Sen, Sajal 1; Huang, Dan-Ying 1; Zang, Yi ; Li, Jia 4; He, Xiao-Peng 2,3; Sessler, Jonathan L.1
刊名	CHEMICAL COMMUNICATIONS
	2021-05-04
页码	4
ISSN号	1359-7345
DOI	10.1039/d0cc08156f
通讯作者	Li, Jia(jli@simm.ac.cn) ; He, Xiao-Peng(xphe@ecust.edu.cn) ; Sessler, Jonathan L.(sessler@cm.utexas.edu)
英文摘要	We report here strategic functionalization of the FDA approved chelator deferasirox (1) in an effort to produce organelle-targeting iron chelators with enhanced activity against A549 lung cancer cells. Derivative 8 was found to have improved antiproliferative activity relative to 1. Fluorescent cell imaging revealed that compound 8 preferentially localises within the lysosome.
资助项目	National Institutes of Health[CA 68682] ; Robert A. Welch Foundation[F-0018] ; NSFC[91853201] ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX03] ; National Key Sci-Tech Special Projects of Infection Diseases of China[2018ZX10732202] ; International Cooperation Program of Shanghai Science and Technology Committee[17520750100] ; China Postdoctoral Science Foundation[2020M681196]
WOS关键词	IRON CHELATOR ; CANCER ; MECHANISMS ; HOMEOSTASIS ; AGENTS
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000649415500001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/296644]
专题	中国科学院上海药物研究所
通讯作者	Li, Jia; He, Xiao-Peng; Sessler, Jonathan L.
作者单位	1.Univ Texas Austin, Dept Chem, 105 E 24th St A5300, Austin, TX 78712 USA 2.East China Univ Sci & Technol, Key Lab Adv Mat, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Ctr Mat & Dynam Chem,Sch Chem & Mol Eng, 130 Meilong Rd, Shanghai 200237, Peoples R China 3.East China Univ Sci & Technol, Joint Int Res Lab Precis Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Ctr Mat & Dynam Chem,Sch Chem & Mol Eng, 130 Meilong Rd, Shanghai 200237, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Steinbrueck, Axel,Sedgwick, Adam C.,Han, Hai-Hao,et al. In vitro studies of deferasirox derivatives as potential organelle-targeting traceable anti-cancer therapeutics[J]. CHEMICAL COMMUNICATIONS,2021:4.
APA	Steinbrueck, Axel.,Sedgwick, Adam C..,Han, Hai-Hao.,Zhao, Michael Y..,Sen, Sajal.,...&Sessler, Jonathan L..(2021).In vitro studies of deferasirox derivatives as potential organelle-targeting traceable anti-cancer therapeutics.CHEMICAL COMMUNICATIONS,4.
MLA	Steinbrueck, Axel,et al."In vitro studies of deferasirox derivatives as potential organelle-targeting traceable anti-cancer therapeutics".CHEMICAL COMMUNICATIONS (2021):4.