Uncommon terpenoids with anti-inflammatory activity from the Hainan soft coral Sinularia tumulosa

doi:10.1016/j.bioorg.2020.104167

	Uncommon terpenoids with anti-inflammatory activity from the Hainan soft coral Sinularia tumulosa
	Cai, You-Sheng 1; Cui, Wan-Xiang 2; Tang, Wei 2; Guo, Yue-Wei 2
刊名	BIOORGANIC CHEMISTRY
	2020-11-01
卷号	104 页码:8
关键词	Peroxide Sinularia tumulosa Terpenoids Anti-inflammatory activity
ISSN号	0045-2068
DOI	10.1016/j.bioorg.2020.104167
通讯作者	Guo, Yue-Wei(ywguo@simm.ac.cn)
英文摘要	One novel sesquiterpenoid containing an unprecedented eight-membered cyclic peroxide motif, sinulatumolin A (1), along with four new related terpenoids, namely sinulatumolins B-E (2-4 and 6), were isolated from South China Sea soft coral Sinularia tumulosa. The structures of all the isolates were elucidated by detailed spectroscopic analysis, chemical transformations, and single X-ray diffraction analysis. Compound 1 represents the first example of sesquiterpene bearing an eight-membered cyclic peroxide ring from soft coral. All the new compounds isolated were evaluated for their anti-inflammatory activity. Compounds 1, 3, 4 and 6 displayed significant TNF-alpha inhibitory activity being comparable with that of the positive control dexamethasone (IC50 = 8.7 mu M), with IC50 values of 7.5, 2.6, 5.5, and 3.6 mu M, respectively.
资助项目	Natural Science Foundation of China[81991521] ; Natural Science Foundation of China[81520108028] ; Natural Science Foundation of China[81973201] ; Natural Science Foundation of China[81860613] ; Drug Innovation Major Project[2018ZX09711-001-001-009] ; SKLDR/SIMM Project[SIMM1903ZZ-04] ; Fundamental Research Funds for the Central Universities[2042019kf0228]
WOS关键词	TIXIER-DURIVAULT ; METABOLITES ; SESQUITERPENOIDS
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号	WOS:000592395300012
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/296460]
专题	中国科学院上海药物研究所
通讯作者	Guo, Yue-Wei
作者单位	1.Wuhan Univ, Inst TCM & Nat Prod, Sch Pharmaceut Sci, Wuhan 430071, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Cai, You-Sheng,Cui, Wan-Xiang,Tang, Wei,et al. Uncommon terpenoids with anti-inflammatory activity from the Hainan soft coral Sinularia tumulosa[J]. BIOORGANIC CHEMISTRY,2020,104:8.
APA	Cai, You-Sheng,Cui, Wan-Xiang,Tang, Wei,&Guo, Yue-Wei.(2020).Uncommon terpenoids with anti-inflammatory activity from the Hainan soft coral Sinularia tumulosa.BIOORGANIC CHEMISTRY,104,8.
MLA	Cai, You-Sheng,et al."Uncommon terpenoids with anti-inflammatory activity from the Hainan soft coral Sinularia tumulosa".BIOORGANIC CHEMISTRY 104(2020):8.