Sesquiterpene lactone dimers from Artemisia lavandulifolia inhibit interleukin-1 beta production in macrophages through activating autophagy

doi:10.1016/j.bioorg.2020.104451

	Sesquiterpene lactone dimers from Artemisia lavandulifolia inhibit interleukin-1 beta production in macrophages through activating autophagy
	Wang, Qiaoqiao 1,2,3,4; Zhang, Tian 5; Ke, Chang-Qiang 1,2; Tang, Chunping 1,2; Yao, Sheng 1,2; Lin, Ligen 5; Ye, Yang 1,2,3,4
刊名	BIOORGANIC CHEMISTRY
	2020-12-01
卷号	105 页码:12
关键词	Artemisia lavandulifolia Sesquiterpene lactone dimers IL-1 beta NLRP3 Autophagy
ISSN号	0045-2068
DOI	10.1016/j.bioorg.2020.104451
通讯作者	Lin, Ligen(ligenl@um.edu.mo) ; Ye, Yang(yye@simm.ac.cn)
英文摘要	Twelve new sesquiterpene lactone dimers, lavandiolides A-L (1-12), were isolated from the whole plants of Artemisia lavandulifolia. Among them, compounds 1-6 are 1,3-linked Diels-Alder adducts between two guaianolide monomers, and 7-12 are 2,4-linked sesquiterpene lactone dimers. Their structures were elucidated by comprehensive analysis of HRESIMS, 1D and 2D NMR spectra. Their absolute configurations were determined by ECD spectra and single-crystal X-ray diffraction analyses with Cu K alpha radiation. The nitric oxide (NO) inhibitory effect of all the isolates was assessed on lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. Compounds 1, 3, 7 and 9 showed potent inhibitory effects on NO production, with IC50 values of 0.61 +/- 0.15, 1.64 +/- 0.04, 1.89 +/- 0.16, and 1.40 +/- 0.23 uM, respectively. Furthermore, compound 1 inhibited NLRP3 (NOD-, LRRand pyrin domain-containing protein 3) inflammasome-mediated interleukin-1 beta (IL-1 beta) production through activating autophagy.
资助项目	National Natural Science Foundation of China[81673327] ; National Natural Science Foundation of China[81903485] ; National Natural Science Foundation of China[81872754] ; National Natural Science Foundation of China[21920102003] ; China National Key RD Program[2017YFE0195100] ; China National Key RD Program[2018YFC1707000] ; National Science and Technology Major Project[2019ZX09201004-003-042] ; University of Macau[MYRG2017-00109-ICMS] ; University of Macau[MYRG2018-00037-ICMS]
WOS关键词	INFLAMMASOME ; GUAIANOLIDES ; PLATFORM
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号	WOS:000603573500009
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/296018]
专题	中国科学院上海药物研究所
通讯作者	Lin, Ligen; Ye, Yang
作者单位	1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Nat Prod Chem Dept, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201203, Peoples R China 4.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 5.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Taipa 999078, Macao, Peoples R China
推荐引用方式 GB/T 7714	Wang, Qiaoqiao,Zhang, Tian,Ke, Chang-Qiang,et al. Sesquiterpene lactone dimers from Artemisia lavandulifolia inhibit interleukin-1 beta production in macrophages through activating autophagy[J]. BIOORGANIC CHEMISTRY,2020,105:12.
APA	Wang, Qiaoqiao.,Zhang, Tian.,Ke, Chang-Qiang.,Tang, Chunping.,Yao, Sheng.,...&Ye, Yang.(2020).Sesquiterpene lactone dimers from Artemisia lavandulifolia inhibit interleukin-1 beta production in macrophages through activating autophagy.BIOORGANIC CHEMISTRY,105,12.
MLA	Wang, Qiaoqiao,et al."Sesquiterpene lactone dimers from Artemisia lavandulifolia inhibit interleukin-1 beta production in macrophages through activating autophagy".BIOORGANIC CHEMISTRY 105(2020):12.