W2476 represses TXNIP transcription via dephosphorylation of FOXO1 at Ser319

doi:10.1111/cbdd.13828

	W2476 represses TXNIP transcription via dephosphorylation of FOXO1 at Ser319
	Zhong, Li 1,2; Liu, Qing 1; Liu, Qiaofeng 3; Zhang, Shikai 4; Cao, Yongbing 4; Yang, Dehua 1; Wang, Ming-Wei 1,2,3
刊名	CHEMICAL BIOLOGY & DRUG DESIGN
	2021-02-16
页码	11
关键词	chromatin immunoprecipitation diabetes transcription TXNIP W2476
ISSN号	1747-0277
DOI	10.1111/cbdd.13828
通讯作者	Yang, Dehua(dhyang@simm.ac.cn) ; Wang, Ming-Wei(mwwang@simm.ac.cn)
英文摘要	Thioredoxin-interacting protein (TXNIP) overexpression is implicated in the pathogenesis of type 2 diabetes. Previous studies have shown that a small molecule compound (W2476) was able to improve beta-cell dysfunction and exert therapeutic effects in diabetic mice via repression of TXNIP signaling pathway. The impact of W2476 on TXNIP transcription was thus investigated using the chromatin immunoprecipitation method. It was found that W2476 promotes competitive binding of forkhead box O1 transcription factor (FOXO1) to the carbohydrate response element (ChoRE) sequence associated with ChoRE-binding protein (ChREBP)/Mlx interacting protein-like(Mlx) complexes. This interaction hinders the attachment of histone acetyltransferase p300 and reduces histone H4 acetylation on the TXNIP promoter, leading to decreasing TXNIP transcription.
资助项目	National Natural Science Foundation of China[81872915] ; National Natural Science Foundation of China[81973373] ; National Natural Science Foundation of China[81773792] ; National Science & Technology Major Project[2018ZX09735-001] ; National Science & Technology Major Project[2018ZX09711002-002-005] ; National Science & Technology Major Project[2018ZX09711002-002-011] ; National Key R&D Program of China[2018YFA0507000] ; Novo Nordisk-CAS Research Fund[NNCAS-2017-1-CC]
WOS研究方向	Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
语种	英语
出版者	WILEY
WOS记录号	WOS:000618522700001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/295812]
专题	中国科学院上海药物研究所
通讯作者	Yang, Dehua; Wang, Ming-Wei
作者单位	1.Chinese Acad Sci, Natl Ctr Drug Screening, CAS Key Lab Receptor Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Fudan Univ, Sch Pharm, Shanghai, Peoples R China 4.Shanghai Univ Tradit Chinese Med, Shanghai TCM Integrated Hosp, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Zhong, Li,Liu, Qing,Liu, Qiaofeng,et al. W2476 represses TXNIP transcription via dephosphorylation of FOXO1 at Ser319[J]. CHEMICAL BIOLOGY & DRUG DESIGN,2021:11.
APA	Zhong, Li.,Liu, Qing.,Liu, Qiaofeng.,Zhang, Shikai.,Cao, Yongbing.,...&Wang, Ming-Wei.(2021).W2476 represses TXNIP transcription via dephosphorylation of FOXO1 at Ser319.CHEMICAL BIOLOGY & DRUG DESIGN,11.
MLA	Zhong, Li,et al."W2476 represses TXNIP transcription via dephosphorylation of FOXO1 at Ser319".CHEMICAL BIOLOGY & DRUG DESIGN (2021):11.