A metal-free method for the facile synthesis of indanones via the intramotecular hydroacylation of 2-vinytbenzaldehyde

doi:10.1039/d0gc03572f

	A metal-free method for the facile synthesis of indanones via the intramotecular hydroacylation of 2-vinytbenzaldehyde
	He, Guoxue 1,2,3; Ma, Jinyu 2,3; Zhou, Jianhui 2,3; Li, Chunpu 2,3; Liu, Hong 1,2,3; Zhou, Yu 1,2,3
刊名	GREEN CHEMISTRY
	2021-01-21
卷号	23 期号:2 页码:1036-1040
ISSN号	1463-9262
DOI	10.1039/d0gc03572f
通讯作者	Liu, Hong(hliu@simm.ac.cn) ; Zhou, Yu(zhouyu@simm.ac.cn)
英文摘要	A facile method for the synthesis of indanones was developed under metal- and additive-free conditions, wherein L-proline served as an efficient and environmentally benign catalyst. Compared with previously synthesized indanones, synthesis by the transition-metal-catalyzed intramolecular hydroacylation of 2-vinylbenzaldehyde provided a more green synthetic pathway to indanone scaffolds with good to excellent yields. More importantly, it could be used to synthsize the anti-AD drug donepezil.
资助项目	National Natural Science Foundation of China[21977106] ; National Natural Science Foundation of China[21672232] ; National Natural Science Foundation of China[21632008] ; National Natural Science Foundation of China[81903434] ; Shanghai Science and Technology Development Funds[19431901000]
WOS研究方向	Chemistry ; Science & Technology - Other Topics
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000613508300039
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/295624]
专题	中国科学院上海药物研究所
通讯作者	Liu, Hong; Zhou, Yu
作者单位	1.UCAS, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	He, Guoxue,Ma, Jinyu,Zhou, Jianhui,et al. A metal-free method for the facile synthesis of indanones via the intramotecular hydroacylation of 2-vinytbenzaldehyde[J]. GREEN CHEMISTRY,2021,23(2):1036-1040.
APA	He, Guoxue,Ma, Jinyu,Zhou, Jianhui,Li, Chunpu,Liu, Hong,&Zhou, Yu.(2021).A metal-free method for the facile synthesis of indanones via the intramotecular hydroacylation of 2-vinytbenzaldehyde.GREEN CHEMISTRY,23(2),1036-1040.
MLA	He, Guoxue,et al."A metal-free method for the facile synthesis of indanones via the intramotecular hydroacylation of 2-vinytbenzaldehyde".GREEN CHEMISTRY 23.2(2021):1036-1040.