Nanobiomaterial-based vaccination immunotherapy of cancer

doi:10.1016/j.biomaterials.2021.120709

	Nanobiomaterial-based vaccination immunotherapy of cancer
	Chen, Fangmin 3,4; Wang, Yingjie 2,3,4; Gao, Jing 3,4; Saeed, Madiha 3,4; Li, Tianliang 3,4; Wang, Weiqi 3,4; Yu, Haijun 1,3,4
刊名	BIOMATERIALS
	2021-03-01
卷号	270 页码:26
关键词	Cancer immunotherapy Nanovaccine Lymph node-targeting Biomimetic nanobiomaterials Antitumor immune response
ISSN号	0142-9612
DOI	10.1016/j.biomaterials.2021.120709
通讯作者	Yu, Haijun(hjyu@simm.ac.cn)
英文摘要	Cancer immunotherapies including cancer vaccines, immune checkpoint blockade or chimeric antigen receptor T cells have been exploited as the attractive treatment modalities in recent years. Among these approaches, cancer vaccines that designed to deliver tumor antigens and adjuvants to activate the antigen presenting cells (APCs) and induce antitumor immune responses, have shown significant efficacy in inhibiting tumor growth, preventing tumor relapse and metastasis. Despite the potential of cancer vaccination strategies, the therapeutic outcomes in preclinical trials are failed to promote their clinical translation, which is in part due to their inefficient vaccination cascade of five critical steps: antigen identification, antigen encapsulation, antigen delivery, antigen release and antigen presentation to T cells. In recent years, it has been demonstrated that various nanobiomaterials hold great potential to enhance cancer vaccination cascade and improve their antitumor performance and reduce the off-target effect. We summarize the cutting-edge advances of nanobiomaterials-based vaccination immunotherapy of cancer in this review. The various cancer nanovaccines including antigen peptide/adjuvant-based nanovaccines, nucleic acid-based nanovaccines as well as biomimetic nanobiomaterials-based nanovaccines are discussed in detail. We also provide some challenges and perspectives associated with the clinical translation of cancer nanovaccines.
资助项目	National Natural Science Foundation of China[32050410287] ; National Natural Science Foundation of China[51873228] ; International Cooperation Project of Science and Technology Commission of Shanghai Municipality[20430711800] ; Youth Innovation Promotion Association of CAS[2014218] ; CAS President's International Fellowship Initiative Program[2019PB0023] ; Postdoctoral Science Foundation of China[2019M661667] ; Shanghai Post-Doctoral Excellence Program[2019116]
WOS研究方向	Engineering ; Materials Science
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000621194400002
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/295584]
专题	中国科学院上海药物研究所
通讯作者	Yu, Haijun
作者单位	1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Univ Sci & Technol China, Nano Sci & Technol Inst, Suzhou 215123, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Chen, Fangmin,Wang, Yingjie,Gao, Jing,et al. Nanobiomaterial-based vaccination immunotherapy of cancer[J]. BIOMATERIALS,2021,270:26.
APA	Chen, Fangmin.,Wang, Yingjie.,Gao, Jing.,Saeed, Madiha.,Li, Tianliang.,...&Yu, Haijun.(2021).Nanobiomaterial-based vaccination immunotherapy of cancer.BIOMATERIALS,270,26.
MLA	Chen, Fangmin,et al."Nanobiomaterial-based vaccination immunotherapy of cancer".BIOMATERIALS 270(2021):26.