Synthetic Studies toward DNA-Encoded Heterocycles Based on the On-DNA Formation of alpha,beta-Unsaturated Ketones

doi:10.1021/acs.orglett.0c04118

	Synthetic Studies toward DNA-Encoded Heterocycles Based on the On-DNA Formation of alpha,beta-Unsaturated Ketones
	Liu, Sixiu 1,2; Qi, Jingjing 1,3; Lu, Weiwei 1; Wang, Xuan 1; Lu, Xiaojie 1
刊名	ORGANIC LETTERS
	2021-02-05
卷号	23 期号:3 页码:908-913
ISSN号	1523-7060
DOI	10.1021/acs.orglett.0c04118
通讯作者	Wang, Xuan(wangxuan2@simm.ac.cn) ; Lu, Xiaojie(xjlu@simm.ac.cn)
英文摘要	Taking advantage of the diversity-oriented synthesis strategy with alpha,beta-unsaturated carbonyl compounds, we have successfully established the DNA-compatible transformations for various heterocyclic scaffolds. The ring-closure reactions for pyrrole, pyrrolidine, pyrazole, pyrazoline, isoxazoline, pyridine, piperidine, cyclohexenone, and 5,8-dihydroimidazo[1,2-a]pyrimidine were elegantly demonstrated in a DNA-compatible format. These efforts paved the way for preparing DNA-encoded libraries with more extensive chemical space.
资助项目	National Natural Science Foundation of China[21877117] ; National Natural Science Foundation of China[91953203] ; National Natural Science Foundation of China[21907103] ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China[2018ZX09711002-005] ; Personalized Medicines-Molecular Signature-based Drug Discovery and Development Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12040330] ; Personalized Medicines-Molecular Signature-based Drug Discovery and Development Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12050405] ; Shanghai Commission of Science and Technology[18431907100]
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000629001700053
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/295385]
专题	中国科学院上海药物研究所
通讯作者	Wang, Xuan; Lu, Xiaojie
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
推荐引用方式 GB/T 7714	Liu, Sixiu,Qi, Jingjing,Lu, Weiwei,et al. Synthetic Studies toward DNA-Encoded Heterocycles Based on the On-DNA Formation of alpha,beta-Unsaturated Ketones[J]. ORGANIC LETTERS,2021,23(3):908-913.
APA	Liu, Sixiu,Qi, Jingjing,Lu, Weiwei,Wang, Xuan,&Lu, Xiaojie.(2021).Synthetic Studies toward DNA-Encoded Heterocycles Based on the On-DNA Formation of alpha,beta-Unsaturated Ketones.ORGANIC LETTERS,23(3),908-913.
MLA	Liu, Sixiu,et al."Synthetic Studies toward DNA-Encoded Heterocycles Based on the On-DNA Formation of alpha,beta-Unsaturated Ketones".ORGANIC LETTERS 23.3(2021):908-913.