Minor immunosuppressive spiroorthoester group-containing pregnane glycosides from the root barks of Periploca sepium

doi:10.1016/j.bioorg.2021.104641

	Minor immunosuppressive spiroorthoester group-containing pregnane glycosides from the root barks of Periploca sepium
	Shao, Xing-Cheng 1,2; Chen, Zhen-Hua 2; Liu, Shuang-Shuang 1,3; Wu, Fei 4; Mu, Hong-Yan 1,2; Wei, Wen-Hui 1,3; Feng, Yi 4; Zuo, Jian-Ping 1,3; Zhang, Ji-Quan 4; He, Shi-Jun 1,3
刊名	BIOORGANIC CHEMISTRY
	2021-03-01
卷号	108 页码:10
关键词	Periploca sepium Pregnane glycosides Spiroorthoester group Immunosuppression
ISSN号	0045-2068
DOI	10.1016/j.bioorg.2021.104641
通讯作者	Zhang, Ji-Quan(13816062506@139.com) ; He, Shi-Jun(heshijun@simm.ac.cn) ; Zhao, Wei-Min(wmzhao@simm.ac.cn)
英文摘要	LC-MS guided chemical investigation of the periploside-rich extract of the root barks of Periploca sepium afforded six new minor pregnane glycosides, named periplosides A1-A6 (1-6). Their structures were characterized on the basis of extensive spectroscopic analysis. Compounds 1-6 were evaluated for their inhibitory activities against the proliferation of T and B lymphocytes in vitro, among them, compound 5 exhibited significant inhibitory activities and the most favorite selective index (SI) values against the proliferation of T lymphocyte (IC50 = 0.30 mu M, SI = 176) and B lymphocyte (IC50 = 0.55 mu M, SI = 97).
资助项目	Science and Technology Commission of Shanghai Municipality[18401931000] ; Personalized Medicines-Molecular Signature-based Drug Discovery and Development, Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12020236] ; National Key Research Development Program of China[2019YFC1711300]
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号	WOS:000624557000012
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/295378]
专题	中国科学院上海药物研究所
通讯作者	Zhang, Ji-Quan; He, Shi-Jun; Zhao, Wei-Min
作者单位	1.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Nat Prod Chem, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 4.Shanghai Univ Tradit Chinese Med, Minist Educ, Engn Res Ctr Modern Preparat Technol Tradit Chine, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Shao, Xing-Cheng,Chen, Zhen-Hua,Liu, Shuang-Shuang,et al. Minor immunosuppressive spiroorthoester group-containing pregnane glycosides from the root barks of Periploca sepium[J]. BIOORGANIC CHEMISTRY,2021,108:10.
APA	Shao, Xing-Cheng.,Chen, Zhen-Hua.,Liu, Shuang-Shuang.,Wu, Fei.,Mu, Hong-Yan.,...&Zhao, Wei-Min.(2021).Minor immunosuppressive spiroorthoester group-containing pregnane glycosides from the root barks of Periploca sepium.BIOORGANIC CHEMISTRY,108,10.
MLA	Shao, Xing-Cheng,et al."Minor immunosuppressive spiroorthoester group-containing pregnane glycosides from the root barks of Periploca sepium".BIOORGANIC CHEMISTRY 108(2021):10.