Design,synthesis and biological evaluation of N-phenylalkyl-substituted tramadol derivatives as novel μ opioid receptor ligands

	Design,synthesis and biological evaluation of N-phenylalkyl-substituted tramadol derivatives as novel μ opioid receptor ligands
	Shen Qing 1; Qian Yuanyuan 1; Xu Xuejun 2; Li Wei 1; Liu Jinggen 2; Fu Wei 1
刊名	Acta Pharmacologica Sinica
	2015
卷号	36 期号:7 页码:887
关键词	μ-opioid receptor tramadol morphine molecular docking
ISSN号	1671-4083
英文摘要	Aim: Tramadol is an atypical opioid analgesic with low potential for tolerance and addiction. However, its opioid activity is much lower than classic opiates such as morphine. To develop novel analgesic and further explore the structure activity relationship (SAR) of tramadol skeleton. Methods: Based on a three-dimensional (3D) structure superimposition and molecular docking study, we found that Ml (the active metabolite of tramadol) and morphine have common pharmacophore features and similar binding modes at the μ opioid receptor in which the substituents on the nitrogen atom of both compounds faced a common hydrophobic pocket formed by Trp2936.48 and Tyr3267.43. In this study, N-phenethylnormorphine was docked to the μ opioid receptor. It was found that the N-substituted group of N-phenethylnormorphine extended into a hydrophobic pocket formed by Trp2936.48 and Tyr3267.43. This hydrophobic interaction may contribute to the improvement of its opioid activities as compared with morphine. The binding modes of Ml, morphine and N-phenethylnormorphine overlapped, indicating that the substituent on the nitrogen atoms of the three compounds may adopt common orientations. A series of N-phenylalkyl derivatives from the tramadol scaffold were designed, synthesized and assayed in order to generate a new type of analgesics. Results: As a result, compound 5b was identified to be an active candidate from these compounds. Furthermore, the binding modes of 5b and morphine derivatives in the μ opioid receptor were comparatively studied. Conclusion: Unlike morphine-derived structures in which bulky N-substitution is associated with improved opioid-like activities, there seems to be a different story for tramadol, suggesting the potential difference of SAR between these compounds. A new type of interaction mechanism in tramadol analogue (5b) was discovered, which will help advance potent tramadol-based analgesic design.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/294861]
专题	中国科学院上海药物研究所
作者单位	1.复旦大学 2.中国科学院上海药物研究所
推荐引用方式 GB/T 7714	Shen Qing,Qian Yuanyuan,Xu Xuejun,et al. Design,synthesis and biological evaluation of N-phenylalkyl-substituted tramadol derivatives as novel μ opioid receptor ligands[J]. Acta Pharmacologica Sinica,2015,36(7):887.
APA	Shen Qing,Qian Yuanyuan,Xu Xuejun,Li Wei,Liu Jinggen,&Fu Wei.(2015).Design,synthesis and biological evaluation of N-phenylalkyl-substituted tramadol derivatives as novel μ opioid receptor ligands.Acta Pharmacologica Sinica,36(7),887.
MLA	Shen Qing,et al."Design,synthesis and biological evaluation of N-phenylalkyl-substituted tramadol derivatives as novel μ opioid receptor ligands".Acta Pharmacologica Sinica 36.7(2015):887.