Insulin-sensitizing effects of a novel α-methyl-α-phenoxylpropionate derivative in vitro

	Insulin-sensitizing effects of a novel α-methyl-α-phenoxylpropionate derivative in vitro
	Wu Haoshu 1; Yu Juanhong 2; Li Yingyin 1; Yang Yushe 2; He Qianjun 1; Lou Yijia 1; Ji Ruyun 2
刊名	Acta Pharmacologica Sinica
	2007
卷号	28 期号:3 页码:417
关键词	YY20 peroxisome proliferator-activated receptor γ insulin sensitivity glucose consumption
ISSN号	1671-4083
英文摘要	Aim: To examine the insulin sensitizing effects of a novel α-methyl-α-phenoxylpropionate derivative YY20 in insulin-sensitive cell lines. Methods: The peroxisome proliferator-activated receptor g (PPARg) agonist bioactivities of YY20 were detected by a preadipocyte differentiation assay. RT-PCR and Western blotting analysis were used to detect the expression of the target gene or protein. The effects of YY20 on insulin-mediated glucose consumption were determined in the HepG2 human hepatocellular carcinoma line. Results: YY20 could enhance the differentiation of preadipocytes to adipocytes and upregulate the gene expression of PPARg2, as well as the protein expression of insulin receptor substrate-1 (IRS-1), glucose transporter-4 (GLUT4), and adiponectin (ACRP30). The effects on GLUT4 and ACRP30 could be reversed by the PPARg inhibitor SR-202. Furthermore, YY20 efficiently reduced glucose consumptions in HepG2 cells after 24 h culture, and the effects were related to insulin and YY20 concentrations. Conclusion: YY20, a potential insulin-sensitizing agent like rosiglitazone, could enhance glucose consumption in HepG2 cells in a concentration- and insulin-dependent manner. It may improve the insulin resistance associated with type 2 diabetes.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/294700]
专题	中国科学院上海药物研究所
作者单位	1.浙江大学 2.中国科学院上海药物研究所
推荐引用方式 GB/T 7714	Wu Haoshu,Yu Juanhong,Li Yingyin,et al. Insulin-sensitizing effects of a novel α-methyl-α-phenoxylpropionate derivative in vitro[J]. Acta Pharmacologica Sinica,2007,28(3):417.
APA	Wu Haoshu.,Yu Juanhong.,Li Yingyin.,Yang Yushe.,He Qianjun.,...&Ji Ruyun.(2007).Insulin-sensitizing effects of a novel α-methyl-α-phenoxylpropionate derivative in vitro.Acta Pharmacologica Sinica,28(3),417.
MLA	Wu Haoshu,et al."Insulin-sensitizing effects of a novel α-methyl-α-phenoxylpropionate derivative in vitro".Acta Pharmacologica Sinica 28.3(2007):417.