Alkaloids from the endophytic fungus Penicillium brefeldianum and their cytotoxic activities

	Alkaloids from the endophytic fungus Penicillium brefeldianum and their cytotoxic activities
	Gao Na; Shang ZhiChun; Yu Pei; Luo Jie; Jian KaiLi; Kong LingYi; Yang MingHua
刊名	CHINESE CHEMICAL LETTERS
	2017
卷号	28 期号:6 页码:1194
关键词	MARINE-DERIVED FUNGUS DIKETOPIPERAZINE ALKALOIDS CONFORMATIONAL-ANALYSIS FILAMENTOUS FUNGI BIOSYNTHESIS ASPERGILLUS APOPTOSIS DIFFERENTIATION ELUCIDATION MYCOTOXINS Penicillium brefeldianum Alkaloids Indoloditerpene Indole-diketopiperazine 13-Membered macrolide Cytotoxicities
ISSN号	1001-8417
英文摘要	One new indoloditerpene, 6,7-dehydropaxilline (1), one new indole-diketopiperazine, spirotryprostatin F (2), and one new 13-membered macrolide, N-demethylmelearoride A (3), as well as 8 known alkaloids (4-11), were isolated from the solid cultures of the endophytic fungus, Penicillium brefeldianum. The structures and absolute configurations of compounds 1-3 were elucidated by comprehensive spectroscopic analysis and the circular dichroism (CD) exciton chirality method. All the metablites were evaluated for their cytotoxic activites against three human tumor cell lines. Compound 2 exhibited cytotoxicities against HepG2 and MDA-MB-231 cells with IC50 values of 14.1 mu mol/1, and 35.5 mu mol/L, respectively. Compound 3 showed moderate activity against HepG2 cells with IC50 values of 36.6 mu mol/L. (C) 2017 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
资助项目	[National Natural Science Foundation of China] ; [Program for Changjiang Scholars and Innovative Research Team in University] ; [Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)] ; [Fundamental Research Funds for the Central Universities]
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/293221]
专题	中国科学院上海药物研究所
作者单位	中国科学院上海药物研究所
推荐引用方式 GB/T 7714	Gao Na,Shang ZhiChun,Yu Pei,et al. Alkaloids from the endophytic fungus Penicillium brefeldianum and their cytotoxic activities[J]. CHINESE CHEMICAL LETTERS,2017,28(6):1194.
APA	Gao Na.,Shang ZhiChun.,Yu Pei.,Luo Jie.,Jian KaiLi.,...&Yang MingHua.(2017).Alkaloids from the endophytic fungus Penicillium brefeldianum and their cytotoxic activities.CHINESE CHEMICAL LETTERS,28(6),1194.
MLA	Gao Na,et al."Alkaloids from the endophytic fungus Penicillium brefeldianum and their cytotoxic activities".CHINESE CHEMICAL LETTERS 28.6(2017):1194.