Bisindole alkaloids with nitric oxide inhibitory activities from an alcohol extract of the Isatis indigotica roots

doi:10.1016/j.fitote.2020.104654

	Bisindole alkaloids with nitric oxide inhibitory activities from an alcohol extract of the Isatis indigotica roots
	Zhang, Dongdong 1,2; Sun, Yu 2; Chen, Zhaoqiang 3; Jia, Qi 1; Zhu, Weiliang 3; Chen, Kaixian 1,3; Li, Yiming 1; Wang, Rui 1
刊名	FITOTERAPIA
	2020-10-01
卷号	146 页码:5
关键词	Isatis indigotica Bisindole alkaloids Nitric oxide production Isatisindigoticanines J and K Isatindigosides H-J
ISSN号	0367-326X
DOI	10.1016/j.fitote.2020.104654
通讯作者	Li, Yiming(ymlius@163.com) ; Wang, Rui(wr@shutcm.edu.cn)
英文摘要	Eight bisindole alkaloids including six undescribed ones (1a/1b-5) were isolated from an alcohol extract of the Isatis indigotica roots. Their structures and absolute configurations were supported by extensive spectroscopic data analysis, including 1D, 2D NMR, HRESIMS data, specific rotation data, and comparison of the experimental and calculated ECD data. Compounds 1a and 1b were determined to be a pair of enantiomers with a ratio of approximately 1:1 by chiral-phase chromatography analysis while compound 4 was elucidated as a new type of bisindole alkaloid with the aglycone categorized as bis(indole-1'/3 ''-yl)methane. All the isolated compounds were tested for their nitric oxide (NO) inhibitory effects and 1-4 and 6 exhibited inhibitory effects with IC50 values ranging from 11.0 to 37.6 mu M.
资助项目	National Natural Science Foundation of China[81573571] ; National Natural Science Foundation of China[81673570] ; Excellent Academic Leaders Program of Shanghai[16XD1403500] ; programs of High level University Innovation Team, Shanghai E-Research Institute of Bioactive Constituents in Traditional Chinese Medicine ; Shanghai Scientific and Technological Innovation Program[18401931100]
WOS关键词	GLYCOSIDES ; GLUCOSIDES
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000580427700008
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/292507]
专题	中国科学院上海药物研究所
通讯作者	Li, Yiming; Wang, Rui
作者单位	1.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China 2.Shaanxi Univ Chinese Med, Sch Pharm, Xianyang 712046, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Dongdong,Sun, Yu,Chen, Zhaoqiang,et al. Bisindole alkaloids with nitric oxide inhibitory activities from an alcohol extract of the Isatis indigotica roots[J]. FITOTERAPIA,2020,146:5.
APA	Zhang, Dongdong.,Sun, Yu.,Chen, Zhaoqiang.,Jia, Qi.,Zhu, Weiliang.,...&Wang, Rui.(2020).Bisindole alkaloids with nitric oxide inhibitory activities from an alcohol extract of the Isatis indigotica roots.FITOTERAPIA,146,5.
MLA	Zhang, Dongdong,et al."Bisindole alkaloids with nitric oxide inhibitory activities from an alcohol extract of the Isatis indigotica roots".FITOTERAPIA 146(2020):5.