Nanotechnology-Based Histone Deacetylase Inhibitors for Cancer Therapy

doi:10.3389/fcell.2020.00400

	Nanotechnology-Based Histone Deacetylase Inhibitors for Cancer Therapy
	Tu, Bin 1,2; Zhang, Meng 2; Liu, Tuanbing 2; Huang, Yongzhuo 1,2,3
刊名	FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
	2020-06-03
卷号	8 页码:8
关键词	Histone deacetylase inhibitors (HDACi) nanotechnology nanomedicine cancer therapy solid tumor targeting drug delivery combination therapy
ISSN号	2296-634X
DOI	10.3389/fcell.2020.00400
通讯作者	Zhang, Meng(Zhangmeng3@simm.ac.cn) ; Huang, Yongzhuo(yzhuang@simm.ac.cn)
英文摘要	Histone deacetylase inhibitors (HDACi) have been approved and achieved success in hematologic malignancies. But its application in solid tumors still confronts big challenges and is hampered by low treatment efficacy. Nanotechnology has been widely applied in cancer therapy, and nanomedicine could improve drug stability, prolong the circulation half-life, and increase intratumoral drug accumulation. Therefore, nanomedicine is a promising strategy to enhance HDACi therapy efficacy. The review provides a summary of the advances of HDACi nanomedicines with a focus on the design principles of the targeting delivery systems for HDACi.
资助项目	NFSC[81925035] ; NFSC[81673382] ; NFSC[81521005] ; Strategic Priority Research Program of CAS[XDA12050307] ; National Special Project for Significant Drugs Development[2018ZX09711002-010-002] ; Fudan-SIMM Joint Research Fund[FU-SIMM20174009]
WOS关键词	TUMOR MICROENVIRONMENT ; CO-DELIVERY ; NANOPARTICLES ; COMBINATION ; DRUG ; VORINOSTAT ; CONJUGATE ; NANOINFORMATICS ; DOXORUBICIN ; CELLS
WOS研究方向	Cell Biology ; Developmental Biology
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000543173700001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/291740]
专题	中国科学院上海药物研究所
通讯作者	Zhang, Meng; Huang, Yongzhuo
作者单位	1.Univ Chinese Acad Sci, Beijing, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China 3.NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipi, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Tu, Bin,Zhang, Meng,Liu, Tuanbing,et al. Nanotechnology-Based Histone Deacetylase Inhibitors for Cancer Therapy[J]. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,2020,8:8.
APA	Tu, Bin,Zhang, Meng,Liu, Tuanbing,&Huang, Yongzhuo.(2020).Nanotechnology-Based Histone Deacetylase Inhibitors for Cancer Therapy.FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,8,8.
MLA	Tu, Bin,et al."Nanotechnology-Based Histone Deacetylase Inhibitors for Cancer Therapy".FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 8(2020):8.